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公开(公告)号：EP3388436B1
公开(公告)日：2020-08-12
申请号：EP18174175.2
申请日：2014-03-17
IPC分类号： C07D487/12 , C07D487/14 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
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公开(公告)号：EP3670515A1
公开(公告)日：2020-06-24
申请号：EP20155968.9
申请日：2014-03-17
IPC分类号： C07D487/14 , C07D487/12 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel pyrimido-diazepinone compounds of formula (I), methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3738964A1
公开(公告)日：2020-11-18
申请号：EP20183712.7
申请日：2014-03-17
IPC分类号： C07D487/14 , C07D487/12 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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公开(公告)号：EP3388436A1
公开(公告)日：2018-10-17
申请号：EP18174175.2
申请日：2014-03-17
IPC分类号： C07D487/12 , C07D487/14 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1,2,3, or 4, Ack1, Ack2, Ab1, DCAMKL1, ABL1, Ab1 mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Ab1, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Ax1, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
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5.发明公开
公开(公告)号：EP2970317A2
公开(公告)日：2016-01-20
申请号：EP14764298.7
申请日：2014-03-17
IPC分类号： C07D487/14 , C07D487/12 , A61K31/519 , A61K31/505 , A61P35/00 , A61P29/00
CPC分类号： C07D513/04 , C07D471/18 , C07D487/04 , C07D487/12 , C07D487/14 , C07D487/16 , C07D487/18 , C07D495/14 , C07D498/04 , C07D498/18 , C07F5/022
摘要： The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), LRKK2, EphA2, polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
摘要翻译： 本发明涉及新的嘧啶并二氮杂酮化合物，调节蛋白激酶的方法，包括MPS1（TTK），ERK5（BMK1，MAPK7），LRKK2，EphA2，polo激酶1,2,3或4，Ack1，Ack2，Ab1 ，DCAMKL1，ABL1，Ab1突变体，DCAMKL2，ARK5，BRK，MKNK2，FGFR4，TNK1，PLK1，ULK2，PLK4，PRKD1，PRKD2，PRKD3，ROS1，RPS6KA6，TAOK1，TAOK3，TNK2，Bcr-Ab1，GAK，cSrc， TPR-Met，Tie2，MET，FGFR3，Aurora，Ax1，Bmx，BTK，c-kit，CHK2，Flt3，MST2，p70S6K，PDGFR，PKB，PKC，Raf，ROCK-H，Rsk1，SGK，TrkA， TrkC，以及这些化合物在治疗各种疾病，病症或病症中的用途。
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