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1.发明公开VARIANTS OF AN ALPHA-AMYLASE WITH IMPROVED PRODUCTION LEVELS IN FERMENTATION PROCESSES 审中-公开α-淀粉酶在发酵过程中提高了生产水平的变化
公开(公告)号：EP2155869A2
公开(公告)日：2010-02-24
申请号：EP08754784.0
申请日：2008-05-29
发明人： AEHLE, Wolfgang , AMIN, Neelam S.
IPC分类号： C12N9/28
CPC分类号： C11D3/38618 , A21D8/042 , C11D3/386 , C12N9/2417 , C12P21/02 , Y02P20/52
摘要： Variants of Bacillus sp. no. 707 alpha amylase are provided that are produced more efficiently and thus more economically. Higher fermentation yields are achieved through introducing amino acid variations that promote solubility of the variant in a fermentation broth. Increased solubility allows more enzyme to remain in solution after expression in a host cell. This in turn increases the efficiency with which the expressed variant enzyme can be recovered from the fermentation broth.
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2.发明公开COMPOSITIONS AND USES FOR AN ALPHA-AMYLASE POLYPEPTIDE OF BACILLUS SPECIES 195 审中-公开组合物和一个APLPHA淀粉酶多肽物质的芽孢杆菌的使用195
公开(公告)号：EP2097519A2
公开(公告)日：2009-09-09
申请号：EP07867644.2
申请日：2007-12-06
发明人： AMIN, Neelam S. , ESTABROOK, Melodie , JONES, Brian E. , KOLKMAN, Marc , VROEMEN, Casper , WEYLER, Walter
CPC分类号： C12N9/2417
摘要： Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
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公开(公告)号：EP2089523A1
公开(公告)日：2009-08-19
申请号：EP07861731.3
申请日：2007-11-05
发明人： AMIN, Neelam S. , BOTT, Richard R. , CERVIN, Marguerite A. , POULOSE, Ayrookaran J. , WEYLER, Walter
CPC分类号： C12N9/16 , C11D3/38636
摘要： The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.
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公开(公告)号：EP4230735A1
公开(公告)日：2023-08-23
申请号：EP22202862.3
申请日：2012-05-04
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, Jr, James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
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公开(公告)号：EP2155870A2
公开(公告)日：2010-02-24
申请号：EP08767923.9
申请日：2008-05-28
发明人： AEHLE, Wolfgang , AMIN, Neelam S.
CPC分类号： C12P19/14 , A21D8/042 , C11D3/386 , C12N9/2417 , D06M16/003
摘要： Variants of B. licheniformis alpha-amylase advantageously exhibit improved enzymatic performance. Suitable variants include those with an altered charge distribution on the surface of the enzyme or with altered active site residues. Structural modeling can inform the choice of amino acid modifications so that modified amino acids correspond to residues found in more active alpha amylases, for example. Compositions comprising the variants are useful in methods of cleaning surfaces, laundering textiles, desizing, treating starch, e.g., liquefaction and saccharification, and hydrolyzing biofilms off various substrates.
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公开(公告)号：EP3575389A3
公开(公告)日：2020-03-04
申请号：EP19182103.2
申请日：2011-05-05
发明人： SOUTER, Philip Frank , WARD, Glenn Steven , POULOSE, Ayrookaran Joseph , ESTELL, David A , KELLIS, Jr. James T. , COLLIER, Katherine D. , CASCAO-PEREIRA, Luis Gustavo , ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam S. , YAO, Jian , AUGUSTYN, Katherine
摘要： A method of treating and/or cleaning a surface, preferably a fabric surface comprising the steps of (i) contacting said surface with a composition in an aqueous wash liquor, said composition comprising an adjunct material and a protease variant wherein said protease variant is a variant of a parent protease said parent protease's sequence being at least 90% identical to the amino acid sequence of SEQ ID NO:1, wherein the amino acid positions of the protease variant are numbered according to the numbering of corresponding amino acid positions in the amino acid sequence of Bacillus amyloliquefaciens subtilisin BPN' shown in SEQ ID NO:2, wherein said protease variant comprises a mutation selected from T022A, T022R, T022Y, T022V, T022Q, T022L, T022W, and (ii) rinsing and/or drying the surface, wherein the temperature of the aqueous liquor is from 5 to 30°C.
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公开(公告)号：EP3486319A2
公开(公告)日：2019-05-22
申请号：EP18197362.9
申请日：2012-05-04
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David, A. , KELLIS, JR, James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
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8.发明公开
公开(公告)号：EP2705146A1
公开(公告)日：2014-03-12
申请号：EP12722991.2
申请日：2012-05-04
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, JR., James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
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公开(公告)号：EP3486319A3
公开(公告)日：2019-07-10
申请号：EP18197362.9
申请日：2012-05-04
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David, A. , KELLIS, JR, James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
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公开(公告)号：EP3095861B1
公开(公告)日：2019-06-26
申请号：EP16177383.3
申请日：2011-05-05
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