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公开(公告)号：EP3095861B1
公开(公告)日：2019-06-26
申请号：EP16177383.3
申请日：2011-05-05
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公开(公告)号：EP3418382A1
公开(公告)日：2018-12-26
申请号：EP18182799.9
申请日：2011-05-05
发明人： ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam S. , AUGUSTYN, Katherine , CASCAO-PEREIRA, Luis Gustavo , COLLIER, Katherine D. , ESTELL, David A. , KELLIS, James T., Jr. , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides isolated subtilisin variants. Specifically, a subtilisin variant is a mature form having proteolytic activity and comprises an amino acid sequence comprising the combination of amino acid substitutions: T022R/A, S101G, S103A, V104I, A232V, and Q245R, wherein the variant is a variant of Bacillus lentus subtilisin GG36 protease comprising the amino acid sequence shown in SEQ ID NO:2, and wherein the variant has at least 90% amino acid sequence identity to the amino acid sequence of SEQ ID NO: 2, and wherein the amino acid positions of the subtilisin variant are numbered according to the numbering of corresponding amino acid positions in the amino acid sequence of B. amyloliquefaciens subtilisin BPN' set forth as SEQ ID NO: 1. In addition, the present invention provides compositions comprising these subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these subtilisin variants and methods of cleaning using the cleaning compositions.
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公开(公告)号：EP3095861A1
公开(公告)日：2016-11-23
申请号：EP16177383.3
申请日：2011-05-05
发明人： SOUTER, Philip Frank , WARD, Glenn Steven , POULOSE, Ayrookaran Joseph , ESTELL, David A. , KELLIS Jr., James T. , COLLIER, Katherine D. , CASCAO-PEREIRA, Luis Gustavo , ALEKSEYEV, Viktor Yuryevich , AMIN, Neelam S. , YAO, Jian , AUGUSTYN, Katherine
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： A method of treating and/or cleaning a surface, preferably a fabric surface comprising the steps of (i) contacting said surface with a composition in an aqueous wash liquor, said composition comprising an adjunct material and a protease variant wherein said protease variant is a variant of a parent protease said parent protease's sequence being at least 90% identical to the amino acid sequence of SEQ ID NO:1, wherein the amino acid positions of the protease variant are numbered according to the numbering of corresponding amino acid positions in the amino acid sequence of Bacillus amyloliquefaciens subtilisin BPN' shown in SEQ ID NO:2, wherein said protease variant comprises a mutation selected from T022A, T022R, T022Y, T022V, T022Q, T022L, T022W, and (ii) rinsing and/or drying the surface, wherein the temperature of the aqueous liquor is from 5 to 30°C.
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4.发明授权USE AND PRODUCTION OF STORAGE-STABLE NEUTRAL METALLOPROTEASE 有权HERTELLUNG LAGERSTABILER中和器METALLOPROTEASE VERWENDUNG
公开(公告)号：EP1934340B1
公开(公告)日：2014-03-12
申请号：EP06826175.9
申请日：2006-10-12
发明人： SHAW, Andrew , WALLACE, Louise , ESTELL, David A. , HOMMES, Ronald , LEE, Sang-Kyu , SADLOWSKI, Eugene Steven , OH, Hiroshi
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D1/02 , C11D3/386 , C11D3/38663 , C12Y304/24
摘要： The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
摘要翻译： 本发明提供包含至少一种具有改善的储存稳定性的中性金属蛋白酶的方法和组合物。 在一些实施方案中，中性金属蛋白酶可用于清洁和其它应用。 在一些特别优选的实施方案中，本发明提供了包含从芽孢杆菌属芽孢杆菌获得的中性金属蛋白酶的方法和组合物。 在一些更特别优选的实施方案中，中性金属蛋白酶从解淀粉芽孢杆菌获得。 在另外的优选实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的变体。 在另外的实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的同系物。 本发明特别用于包括但不限于清洁，漂白和消毒的应用。
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公开(公告)号：EP4230735A1
公开(公告)日：2023-08-23
申请号：EP22202862.3
申请日：2012-05-04
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, Jr, James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
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6.发明公开
公开(公告)号：EP2705146A1
公开(公告)日：2014-03-12
申请号：EP12722991.2
申请日：2012-05-04
发明人： AMIN, Neelam S. , AUGUSTYN, Katherine , BASLER, Joshua R. , CASCAO-PEREIRA, Luis G. , COLLIER, Katherine D. , CONCAR, Edward M. , ESTELL, David A. , KELLIS, JR., James T. , MAGENNIS, Euan John , PISARCHIK, Alexander , POULOSE, Ayrookaran J. , SOUTER, Philip Frank , WARD, Glenn Steven , YAO, Jian
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
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公开(公告)号：EP4159833A2
公开(公告)日：2023-04-05
申请号：EP22182416.2
申请日：2010-12-09
发明人： SOUTER, Philip Frank , WARD, Glenn Steven , BASLER, Jashua Roy , CASCAO-PEREIRA, Luis Gustavo , ESTELL, David A. , KELLIS, James T. Jr. , PISARCHIK, Alexander , POULOUSE, Ayrookaran J. , TORRES-PAZMINO, Daniel , ALEKSEYEV, Viktor Yuryevich
摘要： This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN' subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
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8.发明公开PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 有权蛋白质，改变免疫原性反应的效果，方法及其应用
公开(公告)号：EP1373296A2
公开(公告)日：2004-01-02
申请号：EP02723603.3
申请日：2002-03-22
发明人： ESTELL, David A. , GANSHAW, Grant, C. , HARDING, Fiona, A , LARENAS, Edmund, A. , POULOSE, Ayrookaran, J. , SIKORSKI, Elizabeth, Ellen , ELLIOTT, Russell, Philip
IPC分类号： C07H21/04
CPC分类号： C12N9/54 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K38/00 , A61K2800/72 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
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公开(公告)号：EP1991651B1
公开(公告)日：2013-10-30
申请号：EP07751097.2
申请日：2007-02-16
CPC分类号： C11D3/38654 , C11D1/667 , C11D1/74 , C11D3/0047 , C11D3/2093 , C11D3/221
摘要： The present invention provides methods and compositions for dynamic pH control, particularly in detergent applications. In particularly preferred embodiments, the detergent compositions find use in surface removal of soils from fabrics, including clothing. In some particularly preferred embodiments, the present invention provides combinations of enzymes to provide for dynamic pH control.
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10.发明授权PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 有权蛋白质，改变免疫原性反应的效果，方法及其应用
公开(公告)号：EP1373296B1
公开(公告)日：2011-10-05
申请号：EP02723603.3
申请日：2002-03-22
发明人： ESTELL, David A. , GANSHAW, Grant, C. , HARDING, Fiona, A , LARENAS, Edmund, A. , POULOSE, Ayrookaran, J. , SIKORSKI, Elizabeth, Ellen , ELLIOTT, Russell, Philip
IPC分类号： C07H21/04
CPC分类号： C12N9/54 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K38/00 , A61K2800/72 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
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