专利检索 ap:("Darwin Discovery Limited") AND inv:"KEILY, John, Fraser,Darwin Discovery Limited" 第 1 页

1.

发明公开
HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY 失效
标题翻译： WITH MMP和TNF锁定效果的异羟肟和羧酸衍生物

公开(公告)号：EP0968182A1

公开(公告)日：2000-01-05

申请号：EP97935666.4

申请日：1997-08-07

申请人： Darwin Discovery Limited

发明人： OWEN, David, Alan,Darwin Discovery Limited , MONTANA, John, Gary,Darwin Discovery Limited , KEILY, John, Fraser,Darwin Discovery Limited , WATSON, Robert, John,Darwin Discovery Limited , BAXTER, Andrew, Douglas,Darwin Discovery Limited

IPC分类号： C07C317/44 , C07D209/48 , C07D277/36 , C07D307/38 , C07D213/70 , C07D233/84 , C07D207/40 , C07D233/74 , C07D237/32 , A61K31/19 , A61K31/215

CPC分类号： C07C317/44 , C07C2601/08 , C07D207/48

摘要： The invention concerns hydroxamic acid and carboxylic acid derivatives of formulae (I): B-X-(CH2)n-CHR1-(CH2)m-CONHOH and (Ia): B-S(O)1-2-(CH2)n-CHR1-(CH2)m-COOR2, in which X is O, NR¿3? or S(O)0-2, and the other variables have the definitions given in the claims, having MMP and TNF inhibitory activity.