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1.发明授权
公开(公告)号：EP2729167B1
公开(公告)日：2018-03-14
申请号：EP12740235.2
申请日：2012-07-05
IPC分类号： A61K39/095 , A61P39/04
CPC分类号： A61K39/095 , A61K35/74 , A61K2039/522 , A61K2039/523 , A61K2039/55505 , A61K2039/70 , C12N1/20 , C12N2500/10 , C12N2500/60
摘要： The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
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2.发明公开A PROCESS FOR DETERGENT-FREE PRODUCTION OF OUTER MEMBRANE VESICLES OF A GRAM-NEGATIVE BACTERIUM 有权VERFAHREN ZUR REINIGUNGSMITTELFREIEN HERSTELLUNG DER AUSSENMEMBRANVESIKEL EINES GRAMNEGATIVEN BAKTERIUMS
公开(公告)号：EP2729167A1
公开(公告)日：2014-05-14
申请号：EP12740235.2
申请日：2012-07-05
IPC分类号： A61K39/095 , A61P39/04
CPC分类号： A61K39/095 , A61K35/74 , A61K2039/522 , A61K2039/523 , A61K2039/55505 , A61K2039/70 , C12N1/20 , C12N2500/10 , C12N2500/60
摘要： The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
摘要翻译： 本发明涉及医学微生物学和疫苗领域。 特别地，本发明涉及一种无洗涤剂制备用于疫苗的革兰氏阴性细菌的外膜囊泡（OMV），可通过所述方法获得的OMV以及包含这种OMV的药物组合物的方法。 本发明还涉及本发明的OMV作为特别用于引发免疫应答的方法中的药物的用途。
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