公开(公告)号：EP2749301A1

公开(公告)日：2014-07-02

申请号：EP13199727.2

申请日：2013-12-27

申请人： DePuy Synthes Products, LLC

发明人： Beck, Stefan ,  Niederberger, Lorenz ,  Stohler, Nico

IPC分类号： A61L27/44 ,  A61L27/46 ,  A61L27/48 ,  A61L27/56 ,  C08L67/04 ,  A61L27/50

CPC分类号： A61K9/0012 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/502 ,  A61L27/56 ,  A61L2430/02

摘要： A biocompatible, resorbable composite for osteosynthesis includes osteoconductive particles dispersed within a porous polymer matrix having a plurality of fluid passageways that expose at least a portion of a plurality of the osteoconductive particles to an exterior of the polymer matrix. The composite may further include a chemical additive incorporated within the polymer matrix, the chemical additive being configured to modify one or more of acidity, degradation rate, melting point, hydrophilicity, and hydrophobicity of the polymer matrix. A method for making the composite includes mixing the osteoconductive particles with polymer material and the chemical additive to form a mixture and treating the mixture to bind the osteoconductive particles with the polymer material to create a solid unit.

摘要翻译： 用于骨接合术的生物相容性可吸收复合材料包括分散在具有多个流体通道的多孔聚合物基质内的骨传导性颗粒，其将多个骨传导性颗粒的至少一部分暴露于聚合物基质的外部。 复合材料还可以包括结合在聚合物基体内的化学添加剂，化学添加剂被配置为改变聚合物基质的酸度，降解速率，熔点，亲水性和疏水性中的一种或多种。 制造复合材料的方法包括将骨传导性颗粒与聚合物材料和化学添加剂混合以形成混合物，并将混合物处理以将骨传导性颗粒与聚合物材料结合以产生固体单元。