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1.发明授权
公开(公告)号：EP1140977B1
公开(公告)日：2005-03-09
申请号：EP99965395.9
申请日：1999-12-14
申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts , Europäisches Laboratorium für Molekularbiologie
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6428
摘要： According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90 °C, preferably below 50 °C. The substances that are embedded in the matrix form transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90 °C, preferably below 50 °C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilised by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.
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公开(公告)号：EP0547200B1
公开(公告)日：1998-04-29
申请号：EP92914024.2
申请日：1992-07-06
CPC分类号： C40B40/02 , C07K14/00 , C07K14/245 , C07K16/00 , C07K16/40 , C07K2319/00 , C07K2319/02 , C12N9/88 , C12N15/1037 , C12N15/64
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公开(公告)号：EP0749487A1
公开(公告)日：1996-12-27
申请号：EP95911308.0
申请日：1995-03-07
发明人： SCHIRRMACHER, Volker , KHAZAIE, Khashayarsha , HAAS, Claudia , MOLDENHAUER, Gerd , LITTLE, Melvyn , DÜBEL, Stefan , BREITLING, Frank , KIPRIYANOV, Sergey , GOTTER, Stefanie , RODE, Hans-Jürgen
CPC分类号： A61K39/0011 , A61K2039/6056 , C07K16/1027 , C07K16/2818
摘要： The present invention relates to a bonding reagent characterized in that it comprises a first bonding component for a cell surface protein and a second bonding component for an effector cell molecule having a co-stimulatory effect. The invention further relates to a process for preparing the bonding reagent, and to a vaccine containing said bonding reagent.
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公开(公告)号：EP0547200A1
公开(公告)日：1993-06-23
申请号：EP92914024.0
申请日：1992-07-06
CPC分类号： C40B40/02 , C07K14/00 , C07K14/245 , C07K16/00 , C07K16/40 , C07K2319/00 , C07K2319/02 , C12N9/88 , C12N15/1037 , C12N15/64
摘要： Un vecteur exprime une chaîne unique de domaines variables d'anticorps couplée à la lipoprotéine associée au peptidoglycane (LAP) d'E. coli. L'invention concerne en outre l'utilisation de ce vecteur et un procédé d'isolement de cellules produisant des anticorps spécifiques.
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