公开(公告)号：EP1153282A2

公开(公告)日：2001-11-14

申请号：EP99966859.3

申请日：1999-12-14

申请人： Deutsches KrebsforschungszentrumStiftung des öffentlichen Rechts ,  EUROPÄISCHES LABORATORIUM FÜRMOLEKULARBIOLOGIE

发明人： POUSTKA, Annemarie ,  BREITLING, Frank ,  GROSS, Karl-Heinz ,  DÜBEL, Stefan ,  SAFFRICH, Rainer

IPC分类号： G01N21/64 ,  G01N15/14

CPC分类号： G01N21/6428 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00441 ,  B01J2219/00542 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00725 ,  B82Y30/00 ,  C07K1/047 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N21/6454

摘要： According to the method for detecting optical properties, especially luminescence reactions and refraction behaviour of molecules (14) which are directly or indirectly bound on a support (12), electromagnetic waves, especially laser light (26), are radiated onto the support. The light that is emitted or refracted by the molecules is then detected by a detector (28). The detector and the support are moved in relation to each other during and after the radiation of the electromagnetic waves. The support used is especially a transparent support with integrated position markings (20) which can be detected by a detector, especially an optoelectronic scanning system. At least one of the integrated position markings is selected while the support and the detector are being moved in relation to each other or thereafter so that the light that is detected by the detector can be associated with a location on the support. A device for carrying out the method is provided with a detector, especially an optoelectronic scanning system, for detecting the position markings that are integrated in the support.

公开(公告)号：EP1140977A2

公开(公告)日：2001-10-10

申请号：EP99965395.9

申请日：1999-12-14

申请人： Deutsches KrebsforschungszentrumStiftung des öffentlichen Rechts ,  Europäisches Laboratorium für Molekularbiologie

发明人： POUSTKA, Annemarie ,  BREITLING, Frank ,  GROSS, Karl-Heinz ,  DÜBEL, Stefan ,  SAFFRICH, Rainer

IPC分类号： C07K1/04 ,  C07H21/00 ,  B01J19/00

CPC分类号： G01N21/6452 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00441 ,  B01J2219/00542 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00725 ,  B82Y30/00 ,  C07K1/047 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N21/6428

摘要： According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90 °C, preferably below 50 °C. The substances that are embedded in the matrix form transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90 °C, preferably below 50 °C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilised by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.

摘要翻译： 。根据本发明的方法用于将物质到支撑，爱特别是对于分子库的组合合成单体时，物质被第一个嵌入在基质中的至少一种溶剂由......组成，所述溶剂在温度低于在聚集的固体状态 90℃，优选低于50℃。将物质没有被嵌入在从随后被施加到支撑在聚合的固态运输单元的矩阵，在低于90℃的温度，优选低于50℃ 或者，所述传送单元可以与第二溶剂部分溶解并在聚集的液体状态，在那里它们通过后所述溶剂部分聚集的固体或凝胶状阶段已经完全呼叫或部分蒸发施加到支撑。 在基质中的物质，然后通过修改它们的物理环境动员，并且通过物理过程带入支撑表面的附近。 在这里，物质联系起来与分子。 这种方法可以被重复以多个层施加到在精确位置上的支持。 该方法可以使用，其基本上具有激光打印机或激光复印机或喷墨打印机的结构的装置来进行。