公开(公告)号：EP0920446B1

公开(公告)日：2007-06-06

申请号：EP97932978.6

申请日：1997-07-30

申请人： DeveloGen Israel Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem

发明人： HORNIK, Vered ,  SERI-LEVY, Alon ,  GELLERMAN, Gary ,  GILON, Chaim

IPC分类号： A61K38/04 ,  C07K14/655 ,  A61P5/02

CPC分类号： C07K1/047 ,  A61K38/00 ,  C07K14/001 ,  C07K14/655 ,  C07K14/6555 ,  G01R31/318541 ,  Y02P20/55

摘要： Novel peptide analogs are disclosed. The novel peptides are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions in the treatment of endocrine disorders, neoplasms and metabolic disorders are also disclosed.

公开(公告)号：EP1085896B1

公开(公告)日：2007-05-16

申请号：EP99957020.3

申请日：1999-06-15

申请人： DeveloGen Israel Ltd.

发明人： HORNIK, Vered ,  AFARGAN, Michel, M. ,  GELLERMAN, Gary

IPC分类号： A61K38/04 ,  A61K38/12 ,  C07K7/64 ,  C07K14/655

CPC分类号： C07K14/6555 ,  A61K38/00 ,  G01R31/31816 ,  G01R31/318541

摘要： Novel peptides which are conformationally constrained backbone cyclized somatostatin analogs, having somatostatin receptor sub-type selectivity are disclosed. These patterns of receptor subtype selectivity provide compounds having improved therapeutic utility. Methods for synthesizing the somatostatin analogs and for screening of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions are disclosed.