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公开(公告)号：EP3802563A1
公开(公告)日：2021-04-14
申请号：EP19745141.2
申请日：2019-07-26
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公开(公告)号：EP3281937A1
公开(公告)日：2018-02-14
申请号：EP16183294.4
申请日：2016-08-09
发明人： DE PIZZOL, Maria , SIRICO, Anna , ZIPPOLI, Mara , BIANCHINI, Gianluca , BECCARI, Andrea , ARAMINI, Andrea , LIBERATI, Chiara Rossana Maria
IPC分类号： C07C311/16 , C07C311/21 , C07C311/51 , C07D231/42 , C07D235/30 , C07D249/04 , C07D249/08 , C07D249/14 , C07D257/06 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/04 , C07D285/135
CPC分类号： C07D231/42 , A61K31/18 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/425 , A61K31/433 , C07C311/16 , C07C311/21 , C07C311/51 , C07D235/30 , C07D249/04 , C07D249/08 , C07D249/14 , C07D257/06 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/04 , C07D285/135
摘要： The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I):
Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.摘要翻译： 本发明涉及用作G蛋白偶联受体120（GPR120）和/或40（GPR40）的激动剂的化合物，并且具有式（I）：所述化合物可用于治疗由GPR120调节的疾病或病症和/或 GPR40如糖尿病（特别是2型糖尿病），口服葡萄糖耐量受损，胰岛素抵抗，肥胖，肥胖相关病症，代谢综合征，血脂异常，LDL升高，甘油三酯升高，肥胖诱导的炎症，骨质疏松症和肥胖相关心血管病症。
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3.发明公开2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA 审中-公开2-芳基-4-羟基-1,3-噻唑FOR USE AS TRPM8抑制剂作者神经痛，疼痛，慢性阻塞性肺病和哮喘于治疗
公开(公告)号：EP3157918A1
公开(公告)日：2017-04-26
申请号：EP15730801.6
申请日：2015-06-23
发明人： ARAMINI, Andrea , BIANCHINI, Gianluca , BRANDOLINI, Laura , BECCARI, Andrea , LILLINI, Samuele , NANO, Giuseppe
IPC分类号： C07D417/04 , C07D263/42 , A61K31/426 , A61P29/00
CPC分类号： C07D277/34 , C07D263/42 , C07D417/04
摘要： Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
摘要翻译： 在本发明涉及化合物作用瞬时受体电位阳离子通道亚家族中号构件8（TRP.M8）的选择性拮抗剂，和具有式（I）。 所述化合物可与TRPM8的活性相关的疾病的治疗有用：如疼痛，炎症，局部缺血，神经变性，中风，精神疾病，瘙痒，过敏性肠疾病，冷诱导的和/或加重的呼吸障碍和泌尿疾病。
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4.发明授权(R)-ARYLKYLAMINO DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权（R）-ARYLALKYLAMINODERIVATE和药物组合物含
公开(公告)号：EP1951663B1
公开(公告)日：2016-07-20
申请号：EP06819736.7
申请日：2006-11-24
发明人： ALLEGRETTI, Marcello , MORICONI, Alessio , ARAMINI, Andrea , CESTA, Maria Candida , BECCARI, Andrea , BERTINI, Riccardo
IPC分类号： C07C309/65 , C07C311/03 , C07C311/21 , C07C233/76 , C07D213/70 , C07D213/76 , C07D277/42 , C07D295/10 , C07D295/14 , C07D307/52 , C07D307/68 , C07D333/34 , A61K31/18 , A61K31/165 , A61P9/10
CPC分类号： C07C311/21 , C07C233/76 , C07C309/65 , C07C311/03 , C07D213/70 , C07D213/76 , C07D277/42 , C07D295/108 , C07D295/15 , C07D307/52 , C07D307/68 , C07D333/34
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公开(公告)号：EP3599245A1
公开(公告)日：2020-01-29
申请号：EP18186029.7
申请日：2018-07-27
摘要： The invention relates to IL-17A binding polypeptides, inhibitor of the complex IL17A/IL17RA/ILRC interaction, and the corresponding bioconjugates, their pharmaceutical composition and the medical use thereof in the treatment of inflammatory and autoimmune ophthalmic diseases.
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公开(公告)号：EP3497085B1
公开(公告)日：2020-07-22
申请号：EP17746149.8
申请日：2017-08-07
发明人： DE PIZZOL, Maria , SIRICO, Anna , ZIPPOLI, Mara , BIANCHINI, Gianluca , BECCARI, Andrea , ARAMINI, Andrea , LIBERATI, Chiara Rossana Maria
IPC分类号： C07D231/42 , C07D285/04 , C07C311/16 , C07D285/135 , C07C311/21 , C07D263/50 , C07C311/51 , A61P3/00
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公开(公告)号：EP3497085A1
公开(公告)日：2019-06-19
申请号：EP17746149.8
申请日：2017-08-07
发明人： DE PIZZOL, Maria , SIRICO, Anna , ZIPPOLI, Mara , BIANCHINI, Gianluca , BECCARI, Andrea , ARAMINI, Andrea , LIBERATI, Chiara Rossana Maria
IPC分类号： C07D231/42 , C07D285/04 , C07C311/16 , C07D285/135 , C07C311/21 , C07D263/50 , C07C311/51 , A61P3/00
摘要： The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.
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公开(公告)号：EP3157918B1
公开(公告)日：2019-03-27
申请号：EP15730801.6
申请日：2015-06-23
发明人： ARAMINI, Andrea , BIANCHINI, Gianluca , BRANDOLINI, Laura , BECCARI, Andrea , LILLINI, Samuele , NANO, Giuseppe
IPC分类号： C07D417/04 , C07D263/42 , A61K31/426 , A61P29/00
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公开(公告)号：EP2668160B1
公开(公告)日：2015-08-12
申请号：EP12705078.9
申请日：2012-01-27
发明人： MORICONI, Alessio , BIANCHINI, Gianluca , BRANDOLINI, Laura , ARAMINI, Andrea , LIBERATI, Chiara , BOVOLENTA, Silvia , BECCARI, Andrea , LORENZI, Simone
IPC分类号： C07D213/36 , C07D307/52 , C07D307/56 , C07D333/20 , C07D333/28 , C07D207/323 , A61K31/341 , A61K31/381 , A61K31/4025 , A61K31/4402 , A61P29/00
CPC分类号： C07D213/38 , C07D207/323 , C07D207/335 , C07D213/36 , C07D307/52 , C07D307/56 , C07D333/20 , C07D333/28
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