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公开(公告)号：EP4059497A1
公开(公告)日：2022-09-21
申请号：EP21163292.2
申请日：2021-03-17
发明人： ALLEGRETTI, Marcello , ARAMINI, Andrea , BRANDOLINI, Laura , SIRICO, Anna , CESTA, Maria Candida
IPC分类号： A61K31/405 , A61K31/00 , A61K31/451 , A61P37/08 , C07K16/28 , A61K39/00
摘要： The present invention relates to the use of a C5aR1 inhibitor for the prevention or treatment of a hypersensitivity reaction (HSR) to a taxane in an individual.
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公开(公告)号：EP3406259A1
公开(公告)日：2018-11-28
申请号：EP17172659.9
申请日：2017-05-24
发明人： DE PIZZOL, Maria , ARAMINI, Andrea , SIRICO, Anna , ZIPPOLI, Mara
CPC分类号： A61K38/185 , A61P27/16
摘要： The present invention relates to the use of neurotrophins in the treatment of hearing disorders related to hearing loss using the transtympanic route of administration, in particular in the treatment of sudden deafness, blast-induced hearing loss, ototoxicity, ARHL (age related hearing loss) and noise damage. The invention further relates to the use of compositions containing neurotrophins, in particular NGF, in the treatment of hearing disorders.
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公开(公告)号：EP3497085B1
公开(公告)日：2020-07-22
申请号：EP17746149.8
申请日：2017-08-07
发明人： DE PIZZOL, Maria , SIRICO, Anna , ZIPPOLI, Mara , BIANCHINI, Gianluca , BECCARI, Andrea , ARAMINI, Andrea , LIBERATI, Chiara Rossana Maria
IPC分类号： C07D231/42 , C07D285/04 , C07C311/16 , C07D285/135 , C07C311/21 , C07D263/50 , C07C311/51 , A61P3/00
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公开(公告)号：EP3497085A1
公开(公告)日：2019-06-19
申请号：EP17746149.8
申请日：2017-08-07
发明人： DE PIZZOL, Maria , SIRICO, Anna , ZIPPOLI, Mara , BIANCHINI, Gianluca , BECCARI, Andrea , ARAMINI, Andrea , LIBERATI, Chiara Rossana Maria
IPC分类号： C07D231/42 , C07D285/04 , C07C311/16 , C07D285/135 , C07C311/21 , C07D263/50 , C07C311/51 , A61P3/00
摘要： The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.
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公开(公告)号：EP3630159A1
公开(公告)日：2020-04-08
申请号：EP18725242.4
申请日：2018-05-22
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公开(公告)号：EP3281937A1
公开(公告)日：2018-02-14
申请号：EP16183294.4
申请日：2016-08-09
发明人： DE PIZZOL, Maria , SIRICO, Anna , ZIPPOLI, Mara , BIANCHINI, Gianluca , BECCARI, Andrea , ARAMINI, Andrea , LIBERATI, Chiara Rossana Maria
IPC分类号： C07C311/16 , C07C311/21 , C07C311/51 , C07D231/42 , C07D235/30 , C07D249/04 , C07D249/08 , C07D249/14 , C07D257/06 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/04 , C07D285/135
CPC分类号： C07D231/42 , A61K31/18 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/425 , A61K31/433 , C07C311/16 , C07C311/21 , C07C311/51 , C07D235/30 , C07D249/04 , C07D249/08 , C07D249/14 , C07D257/06 , C07D261/16 , C07D263/50 , C07D275/03 , C07D277/52 , C07D285/04 , C07D285/135
摘要： The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I):
Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabetes (particularly type 2 diabetes), impaired oral glucose tolerance, insulin resistance, obesity, obesity related disorders, metabolic syndrome, dyslipidemia, elevated LDL, elevated triglycerides, obesity induced inflammation, osteoporosis and obesity related cardiovascular disorders.摘要翻译： 本发明涉及用作G蛋白偶联受体120（GPR120）和/或40（GPR40）的激动剂的化合物，并且具有式（I）：所述化合物可用于治疗由GPR120调节的疾病或病症和/或 GPR40如糖尿病（特别是2型糖尿病），口服葡萄糖耐量受损，胰岛素抵抗，肥胖，肥胖相关病症，代谢综合征，血脂异常，LDL升高，甘油三酯升高，肥胖诱导的炎症，骨质疏松症和肥胖相关心血管病症。
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