公开(公告)号：EP3354739A1

公开(公告)日：2018-08-01

申请号：EP17206033.7

申请日：2011-05-17

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  MERLO, Ann Owens ,  GACHOTTE, Daniel ,  ROESSLER, Paul Gordon ,  BEVAN, Scott ,  KUNER, Jerry M. ,  METZ, James G.

IPC分类号： C12N15/82 ,  C12N15/87 ,  C12N5/04 ,  C12N5/14 ,  C12N9/10 ,  C12N9/12 ,  C12P7/64

CPC分类号： C12N15/8247 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427

摘要： The invention provides recombinant host organisms ( e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins ( e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms ( e.g., to obtain PUFAs) as well as products obtained from such organisms ( e.g., oil and/or seed).

公开(公告)号：EP2737054A2

公开(公告)日：2014-06-04

申请号：EP12816868.9

申请日：2012-07-26

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  GACHOTTE, Daniel ,  MERLO, Ann Owens ,  PAREDDY, Dayakar Reddy ,  METZ, James ,  BEVAN, Scott ,  KUNER, Jerry

IPC分类号： C12N5/04

CPC分类号： C12N15/8247 ,  A01H5/10 ,  A23L11/07 ,  A23V2002/00 ,  A61K31/202 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y203/01085

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：EP3517617A1

公开(公告)日：2019-07-31

申请号：EP19162968.2

申请日：2011-05-17

申请人： Dow Agrosciences LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  MERLO, Ann Owens ,  GACHOTTE, Daniel ,  ROESSLER, Paul Gordon ,  BEVAN, Scott ,  KUNER, Jerry M. ,  METZ, James G.

IPC分类号： C12N15/82 ,  C12N15/87 ,  C12N5/04 ,  C12N5/14 ,  C12N9/10 ,  C12N9/12 ,  C12P7/64 ,  C07C11/21

摘要： The invention provides recombinant host organisms ( e . g ., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins ( e . g ., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms ( e . g ., to obtain PUFAs) as well as products obtained from such organisms ( e . g ., oil and/or seed).

公开(公告)号：EP3677669A1

公开(公告)日：2020-07-08

申请号：EP19204216.6

申请日：2012-07-26

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  GACHOTTE, Daniel J. ,  MERLO, Ann Owens ,  PARREDY, Dayakar ,  METZ, James ,  BEVAN, Scott ,  KUNER, Jerry

IPC分类号： C12N5/04

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：EP3483260A1

公开(公告)日：2019-05-15

申请号：EP18213416.3

申请日：2012-07-26

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  GACHOTTE, Daniel ,  MERLO, Ann Owens ,  PARREDY, Dayakar Reddy ,  METZ, James ,  BEVAN, Scott ,  KUNER, Jerry

IPC分类号： C12N5/04 ,  C12P7/64 ,  A01H5/10 ,  C12N9/10 ,  C12N9/12

摘要： The invention provides recombinant host organisms genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms as well as products obtained from such organisms.

公开(公告)号：EP2571994B1

公开(公告)日：2017-12-13

申请号：EP11784114.8

申请日：2011-05-17

申请人： Dow AgroSciences LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  MERLO, Ann Owens ,  GACHOTTE, Daniel ,  ROESSLER, Paul Gordon ,  BEVAN, Scott ,  KUNER, Jerry M. ,  METZ, James G.

IPC分类号： C12N15/82 ,  C12N15/87 ,  C12N5/00 ,  C12N5/02 ,  C12N5/04 ,  C12N5/10 ,  C12N9/10 ,  C12N9/12 ,  C12P7/64

CPC分类号： C12N15/8247 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed),

公开(公告)号：EP2571994A1

公开(公告)日：2013-03-27

申请号：EP11784114.8

申请日：2011-05-17

申请人： Dow AgroSciences, LLC ,  DSM IP Assets B.V.

发明人： WALSH, Terence A. ,  MERLO, Ann Owens ,  GACHOTTE, Daniel ,  ROESSLER, Paul Gordon ,  BEVAN, Scott ,  KUNER, Jerry M. ,  METZ, James G.

IPC分类号： C12N15/82 ,  C12N15/87 ,  C12N5/00 ,  C12N5/02 ,  C12N5/04 ,  C12N5/10

CPC分类号： C12N15/8247 ,  C12N9/1029 ,  C12N9/1288 ,  C12P7/6427

摘要： The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed),

摘要翻译： 本发明提供了用多不饱和脂肪酸（PUFA）合酶系统和一种或多种辅助蛋白质（例如，PPT酶和/或ACoAS）遗传修饰的重组宿主生物（例如，植物），其允许和/或改善PUFA的生产 宿主生物体。 本发明还涉及制备和使用这些生物体（例如获得PUFA）以及从这些生物（例如油和/或种子）获得的产品的方法。

公开(公告)号：EP2872630A1

公开(公告)日：2015-05-20

申请号：EP13820187.6

申请日：2013-07-16

申请人： Dow AgroSciences LLC

发明人： MERLO, Donald J. ,  LARRINUA, Ignacio ,  BEVAN, Scott

IPC分类号： C12N15/10 ,  C12N15/63

CPC分类号： C07K14/415 ,  C12N15/63 ,  C12N15/8216

摘要： This disclosure concerns methods for the design of synthetic nucleic acid sequences that encode polypeptide amino acid repeat regions. This disclosure also concerns the use of such sequences to express a polypeptide of interest that comprises amino acid repeat regions, and organisms comprising such sequences.

公开(公告)号：EP2585600A2

公开(公告)日：2013-05-01

申请号：EP11799019.2

申请日：2011-06-24

申请人： Dow AgroSciences LLC

发明人： MERLO, Ann Owens ,  GACHOTTE, Daniel, J ,  THOMPSON, Mark, A. ,  WALSH, Terence, A. ,  BEVAN, Scott

IPC分类号： C12N15/53 ,  C12N9/02 ,  C12N1/19 ,  A01H5/00 ,  A01H5/10 ,  C12P7/64

CPC分类号： C12N9/0083 ,  C12N15/8247

摘要： Compositions and methods include genetically encoding and expressing a novel delta-9 desaturase in plant cells. In some embodiments, methods of expressing nucleic acids in a plant cell to take advantage of the delta-9 desaturase enzyme's activity, such that the percent composition of saturated fatty acids in plant seeds is decreased and there is a concomitant increase in ω-7 fatty acids. In other embodiments, amino acid sequences have delta-9 desaturase activity. Methods can involve expression of delta-9 desaturase in plant cells, plant materials, and whole plants for the purpose of increasing the amount of unusual fatty acids in whole plants, plant seeds, and plant materials, for example, seeds.

公开(公告)号：EP2872630B1

公开(公告)日：2018-10-17

申请号：EP13820187.6

申请日：2013-07-16

申请人： Dow AgroSciences LLC

发明人： MERLO, Donald J. ,  LARRINUA, Ignacio ,  BEVAN, Scott

IPC分类号： C12N15/10 ,  C12N15/63

CPC分类号： C07K14/415 ,  C12N15/63 ,  C12N15/8216

摘要： This disclosure concerns methods for the design of synthetic nucleic acid sequences that encode polypeptide amino acid repeat regions. This disclosure also concerns the use of such sequences to express a polypeptide of interest that comprises amino acid repeat regions, and organisms comprising such sequences.