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公开(公告)号：EP3068764B1
公开(公告)日：2019-02-20
申请号：EP14805449.7
申请日：2014-11-12
发明人： ALLEN, Laura , SANFORD, Melanie , LEE, Shin Hee , BLAND, Douglas , CHENG, Yang , ROTH, Gary , MUHUHI, Joseck
IPC分类号： C07D213/803
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公开(公告)号：EP3331857A1
公开(公告)日：2018-06-13
申请号：EP16833891.1
申请日：2016-08-04
IPC分类号： C07D213/26
CPC分类号： C07D213/79 , C07D213/26 , C07D213/76 , C07D213/803 , C07D213/84 , C07D213/85 , C07D215/04 , C07D215/18 , C07D215/26 , C07D217/02 , C07D217/22 , C07D237/08 , C07D237/12 , C07D241/16
摘要： Disclosed are mild temperature (e.g., from 0 to 80° C.) SNAr fluorinations of a variety of halide and sulfonate substituted aryl and heteroaryl substrates using NMe4F.
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公开(公告)号：EP3068764A1
公开(公告)日：2016-09-21
申请号：EP14805449.7
申请日：2014-11-12
发明人： ALLEN, Laura , SANFORD, Melanie , LEE, Shin Hee , BLAND, Douglas , CHENG, Yang , ROTH, Gary , MUHUHI, Joseck
IPC分类号： C07D213/803
CPC分类号： C07D213/803
摘要： Methods of preparing a fluorinated substrate by combining potassium fluoride, a quaternary ammonium salt, and a substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide the fluorinated substrate are disclosed.
摘要翻译： 公开了通过组合氟化钾，季铵盐和被至少一个氯，溴，磺酰基或硝基取代的基材以由此提供氟化基材来制备氟化基材的方法。
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公开(公告)号：EP3068765B1
公开(公告)日：2018-07-04
申请号：EP14805454.7
申请日：2014-11-12
发明人： ALLEN, Laura , SANFORD, Melanie , BLAND, Douglas
IPC分类号： C07D213/803
CPC分类号： C07B39/00 , C07D213/79 , C07D213/803
摘要： Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate.
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公开(公告)号：EP3068765B9
公开(公告)日：2018-12-12
申请号：EP14805454.7
申请日：2014-11-12
发明人： ALLEN, Laura , SANFORD, Melanie , BLAND, Douglas
IPC分类号： C07D213/803
CPC分类号： C07B39/00 , C07D213/79 , C07D213/803
摘要： Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate.
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公开(公告)号：EP3068765A1
公开(公告)日：2016-09-21
申请号：EP14805454.7
申请日：2014-11-12
发明人： ALLEN, Laura , SANFORD, Melanie , BLAND, Douglas
IPC分类号： C07D213/803
CPC分类号： C07B39/00 , C07D213/79 , C07D213/803
摘要： Methods of preparing a fluorinated aryl or heteroaryl substrate by combining a quaternary ammonium cyanide and an aryl or heteroaryl substrate substituted with at least one chloro, bromo, sulfonyl, or nitro group to thereby provide a mixture, and combining the mixture with hexafluorobenzene to thereby provide the fluorinated substrate.
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