公开(公告)号：EP0998572A2

公开(公告)日：2000-05-10

申请号：EP98936003.7

申请日：1998-07-24

申请人： Du Pont Pharmaceuticals Company

发明人： ARNER, Elizabeth, C. ,  BURN, Timothy, C. ,  COPELAND, Robert, A. ,  DECICCO, Carl, P. ,  LIU, Ruiqin ,  MAGOLDA, Ronald ,  PRATTA, Michael ,  SOLOMON, Kimberly, A. ,  TORTORELLA, Micky, D. ,  TRZASKOS, James, M. ,  YANG, Fude

IPC分类号： C12N15/57 ,  C12N9/64 ,  C07K16/40 ,  C12N1/19 ,  C12N5/10 ,  C12Q1/68 ,  C12Q1/37 ,  A61K38/55 ,  A61K39/395 ,  G01N33/573 ,  G01N33/68

CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K16/40 ,  C12Q1/37 ,  G01N33/6887 ,  G01N2333/96486 ,  G01N2500/00 ,  G01N2800/102

摘要： The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu?373-Ala374¿. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.