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公开(公告)号：EP2903635B1
公开(公告)日：2018-07-18
申请号：EP13771540.5
申请日：2013-10-04
发明人： DOLLY, James Oliver , WANG, Jiafu , MENG, Jianghui
CPC分类号： C12N9/96 , A61K38/4893 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C07K2319/55 , C12N9/52 , C12N9/6489
摘要： The present invention is directed to analgesic Clostridial neurotoxin derivatives comprising polypeptides having a long-lasting SNARE protein-selective endopeptidase activity. These derivatives selectively bind to and are internalized by non-neuronal cells secreting cytokines or sensory neurons in preference to motor neurons or autonomic neurons. The invention is also directed to nucleic acid constructs encoding such polypeptides, and methods of making such derivatives and nucleic acid constructs, and methods of treating pain, such as chronic pain, by administering such derivatives to a patient suffering from, or at risk of suffering from such pain.
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2.发明公开
公开(公告)号：EP3087089A1
公开(公告)日：2016-11-02
申请号：EP14821171.7
申请日：2014-12-19
发明人： DOLLY, James Oliver , WANG, Jiafu , MENG, Jianghui
IPC分类号： C07K14/33
CPC分类号： C12N9/52 , A61K38/00 , A61K38/4893 , C07K14/33 , C07K2319/00 , C07K2319/50 , C12Y304/24069 , Y02A50/469
摘要： The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In preferred embodiments, the invention includes methods and compositions for the treatment of inflammatory disorders (such as arthritis); chronic pain, such as neuropathic pain and inflammatory pain through the use of such Clostridial neurotoxin derivatives, including those derived from an intact BoNT/A having an LC/E-derived endopeptidase joined to the LC/A endopeptidase.
摘要翻译： 本发明包括含有至少两个轻链内肽酶结构域的梭菌神经毒素衍生物和编码这种梭菌神经毒素衍生物的核酸。 在优选的实施方案中，本发明包括用于治疗炎症性疾病（例如关节炎）的方法和组合物; 包括通过使用这种梭菌神经毒素衍生物的神经性疼痛和炎性疼痛的慢性疼痛，包括衍生自具有连接到LC / A内肽酶的LC / E衍生的内肽酶的完整BoNT / A的那些。
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公开(公告)号：EP3087089B1
公开(公告)日：2018-02-21
申请号：EP14821171.7
申请日：2014-12-19
发明人： DOLLY, James Oliver , WANG, Jiafu , MENG, Jianghui
CPC分类号： C12N9/52 , A61K38/00 , A61K38/4893 , C07K14/33 , C07K2319/00 , C07K2319/50 , C12Y304/24069 , Y02A50/469
摘要： The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In preferred embodiments, the invention includes methods and compositions for the treatment of inflammatory disorders (such as arthritis); chronic pain, such as neuropathic pain and inflammatory pain through the use of such Clostridial neurotoxin derivatives, including those derived from an intact BoNT/A having an LC/E-derived endopeptidase joined to the LC/A endopeptidase.
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公开(公告)号：EP2903635A1
公开(公告)日：2015-08-12
申请号：EP13771540.5
申请日：2013-10-04
发明人： DOLLY, James Oliver , WANG, Jiafu , MENG, Jianghui
CPC分类号： C12N9/96 , A61K38/4893 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C07K2319/55 , C12N9/52 , C12N9/6489
摘要： The present invention is directed to analgesic Clostridial neurotoxin derivatives comprising polypeptides having a long-lasting SNARE protein-selective endopeptidase activity. These derivatives selectively bind to and are internalized by non-neuronal cells secreting cytokines or sensory neurons in preference to motor neurons or autonomic neurons. The invention is also directed to nucleic acid constructs encoding such polypeptides, and methods of making such derivatives and nucleic acid constructs, and methods of treating pain, such as chronic pain, by administering such derivatives to a patient suffering from, or at risk of suffering from such pain.
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