公开(公告)号：EP2153232A1

公开(公告)日：2010-02-17

申请号：EP08767809.0

申请日：2008-05-19

申请人： Duke University

发明人： PATZ, Edward, F., Jr. ,  CAMPA, Michael J.

IPC分类号： G01N33/574

CPC分类号： G01N33/57423 ,  G06F19/00

摘要： Methods and kits are provided for determining the probability of lung cancer, for managing treatment of subjects with potential lung cancer and for molecular staging of lung tumors. The methods include determining an amount of each member of a panel of biomarkers in a sample from the subject, wherein the panel of biomarkers comprises at least two of the proteins alpha-1-antitrypsin, carcinoembryonic antigen, squamous cell carcinoma antigen, retinol binding protein, transferrin, and haptoglobin; and assigning the subject to a group having a higher or lower probability of lung cancer based on the determined amount of each biomarker the panel.

公开(公告)号：EP3003372A2

公开(公告)日：2016-04-13

申请号：EP14806951.1

申请日：2014-06-07

申请人： Duke University

发明人： PATZ, Jr., Edward F. ,  CAMPA, Michael J. ,  GOTTLIN, Elizabeth ,  HAYNES, Barton F. ,  LIAO, Hua-Xin ,  MOODY, M., Anthony

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/72 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6872 ,  G01N33/6878 ,  G01N2333/4716

摘要： Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.

公开(公告)号：EP3632467A1

公开(公告)日：2020-04-08

申请号：EP19191054.6

申请日：2014-06-07

申请人： Duke University

发明人： PATZ, Jr., Edward F. ,  CAMPA, Michael J. ,  GOTTLIN, Elizabeth ,  HAYNES, Barton F. ,  LIAO, Hua-Xin ,  MOODY, M., Anthony

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K14/72 ,  G01N33/68 ,  C07K16/18 ,  C07K16/28

摘要： Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.

公开(公告)号：EP3003372B1

公开(公告)日：2019-10-09

申请号：EP14806951.1

申请日：2014-06-07

申请人： Duke University

发明人： PATZ, Jr., Edward F. ,  CAMPA, Michael J. ,  GOTTLIN, Elizabeth ,  HAYNES, Barton F. ,  LIAO, Hua-Xin ,  MOODY, M., Anthony

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K14/72 ,  G01N33/68 ,  C07K16/18