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公开(公告)号：EP3003372A2
公开(公告)日：2016-04-13
申请号：EP14806951.1
申请日：2014-06-07
申请人： Duke University
发明人： PATZ, Jr., Edward F. , CAMPA, Michael J. , GOTTLIN, Elizabeth , HAYNES, Barton F. , LIAO, Hua-Xin , MOODY, M., Anthony
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K14/72 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/73 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6872 , G01N33/6878 , G01N2333/4716
摘要： Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
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2.发明授权
公开(公告)号：EP2739312B1
公开(公告)日：2017-10-04
申请号：EP12819608.6
申请日：2012-08-03
发明人： WHITTLE, James , HARRISON, Stephen, C. , HAYNES, Barton, F. , LIAO, Hua-xin , MOODY, M., Anthony , KEPLER, Thomas, B. , SCHMIDT, Aaron, G
CPC分类号： C07K16/1018 , A61K31/713 , A61K38/02 , A61K47/6841 , A61K51/1006 , C07K2299/00 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76
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公开(公告)号：EP2331133A2
公开(公告)日：2011-06-15
申请号：EP09811854.0
申请日：2009-09-08
申请人： Duke University
IPC分类号： A61K39/395 , A61P31/18
CPC分类号： C07K16/44 , C07K16/28 , C07K2317/21 , C07K2317/76
摘要： The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.
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公开(公告)号：EP3632467A1
公开(公告)日：2020-04-08
申请号：EP19191054.6
申请日：2014-06-07
申请人： Duke University
发明人： PATZ, Jr., Edward F. , CAMPA, Michael J. , GOTTLIN, Elizabeth , HAYNES, Barton F. , LIAO, Hua-Xin , MOODY, M., Anthony
摘要： Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
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公开(公告)号：EP3003372B1
公开(公告)日：2019-10-09
申请号：EP14806951.1
申请日：2014-06-07
申请人： Duke University
发明人： PATZ, Jr., Edward F. , CAMPA, Michael J. , GOTTLIN, Elizabeth , HAYNES, Barton F. , LIAO, Hua-Xin , MOODY, M., Anthony
IPC分类号： A61K39/395 , A61K39/00 , C07K14/72 , G01N33/68 , C07K16/18
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公开(公告)号：EP3271022A2
公开(公告)日：2018-01-24
申请号：EP16765900.2
申请日：2016-03-21
发明人： HAYNES, Barton, F. , LIAO, Hua-xin , MOODY, M., Anthony , WILLIAMS, Latonya , WIEHE, Kevin, J. , OFEK, Gilad, Adi
IPC分类号： A61P31/18 , A61K39/42 , A61K39/395 , C12N15/13 , C07K14/16
CPC分类号： A61K39/42 , C07K16/1045 , C07K16/1063 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention is directed to HIV- 1 neutralizing antibodies and methods for their uses.
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7.发明公开HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE 审中-公开SCHUTZ- UND IMPFSTOFF GEGEN DIE MUTTER-KIND-ÜBERTRAGUNGVON HIV-1
公开(公告)号：EP3049524A1
公开(公告)日：2016-08-03
申请号：EP14849379.4
申请日：2014-09-26
申请人： Duke University
发明人： HAYNES, Barton, F. , PERMAR, Sallie , MOODY, M., Anthony , GAO, Feng , LIAO, Hua-Xin , TOMARAS, Georgia , MONTEFIORI, David, C.
IPC分类号： C12N15/49 , C07K14/16 , A61K31/7088 , A61P31/18 , G01N33/50
CPC分类号： A61K31/7088 , A61K2039/505 , C07K14/005 , C07K16/1063 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C12N2770/00041 , G01N33/56988 , G01N2800/50
摘要： The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.
摘要翻译： 本发明提供诱导和增强抗体应答的组合物和方法，包括但不限于在有需要的受试者中结合HIV-1的IgG应答，其中所述抗体应答的诱导/升高的血浆水平，例如V3和/或 CD4结合位点抗体应答超过阈值水平，与HIV-1的母婴传播风险（MTCT）相关。
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公开(公告)号：EP2822599A1
公开(公告)日：2015-01-14
申请号：EP13757076.8
申请日：2013-03-05
申请人： Duke University
CPC分类号： A61K39/21 , A61K31/01 , A61K39/12 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C12N7/00 , C12N2740/16134
摘要： The present invention relates, in general, to a method of inducing an immune response to HlV-1 in a mammal and, in particular, to a vaccine formulation suitable for use in such a method comprising an HIV-1 envelope (Env) immunogen comprising recombinant Envs with some degree of high- mannose glycan residues and a Toll-like receptor (TLR) agonist-supplemented squalene-based adjuvant.
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9.发明公开
公开(公告)号：EP2739312A2
公开(公告)日：2014-06-11
申请号：EP12819608.6
申请日：2012-08-03
发明人： WHITTLE, James , HARRISON, Stephen, C. , HAYNES, Barton, F. , LIAO, Hua-xin , MOODY, M., Anthony , KEPLER, Thomas, B. , SCHMIDT, Aaron, G
IPC分类号： A61K39/395 , A61K31/728 , A61K38/16 , A61K38/17 , A61K47/48 , A61P31/16 , A61P31/00
CPC分类号： C07K16/1018 , A61K31/713 , A61K38/02 , A61K47/6841 , A61K51/1006 , C07K2299/00 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76
摘要： The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
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公开(公告)号：EP2694542A2
公开(公告)日：2014-02-12
申请号：EP12768353.0
申请日：2012-04-09
申请人： Duke University , The Government of The United States, as represented by The Secretary of The Army, on behalf of Walter Reed Army
发明人： HAYNES, Barton, F. , LIAO, Hua-Xin , MOODY, M., Anthony , TOMARAS, Georgia, D. , KIM, Jerome , MICHAEL, Nelson
CPC分类号： C07K16/087
摘要： The present invention relates, in general to herpes simplex virus (HSV) and, particular, to antibodies that are specific for glycoprotein D (gD) of HSV. The invention also relates to prophylactic and therapeutic uses of such antibodies.
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