公开(公告)号：EP2539365A2

公开(公告)日：2013-01-02

申请号：EP11747821.4

申请日：2011-02-25

申请人： Duke University

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  TOMARAS, Georgia ,  KEPLER, Thomas, B. ,  HWANG, Kwan-Ki ,  ALAM, S., Munir ,  LIU, Yang ,  HOLL, T., Matt ,  YANG, Guang ,  KELSOE, Garnett ,  BONSIGNORI, Mattia

IPC分类号： C07K16/10 ,  C12N15/13 ,  A61K39/42 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/0005 ,  A61K39/0258 ,  A61K2039/53 ,  A61K2039/58 ,  C07K16/1063 ,  C12N2740/16034 ,  C12N2740/16134

摘要： The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.