公开(公告)号：EP2556148A2

公开(公告)日：2013-02-13

申请号：EP11766283.3

申请日：2011-04-11

申请人： Duke University

发明人： HAYNES, Barton, F. ,  BONSIGNORI, Mattia ,  HWANG, Kwan-Ki ,  LIAO, Hua-Xin ,  MONTEFIORI, David, C. ,  LUFTIG, Micah, A.

IPC分类号： C12N5/0781 ,  C12N5/10 ,  C07K16/18

CPC分类号： C07K16/00 ,  C07K16/1045 ,  C07K2317/76

摘要： The present invention relates, in general, to human B cells, and, in particular to a method of immortalizing and cloning human B cells and to monoclonal antibodies derived therefrom. The invention further relates to methods of using the monoclonal antibodies for therapeutic and diagnostic purposes.

公开(公告)号：EP2335069A2

公开(公告)日：2011-06-22

申请号：EP09816574.9

申请日：2009-09-24

申请人： Duke University

发明人： TOMARAS, Georgia ,  HAYNES, Barton, F. ,  LIU, Pinghuang ,  YATES, Nicole ,  HWANG, Kwan-Ki

IPC分类号： G01N33/53 ,  C12Q1/68 ,  C07K16/10

CPC分类号： C07K16/1063 ,  G01N33/56988

摘要： The present invention relates, in general, to HIV and, in particular to a method of detecting anti-HIV antibodies and antibody-HIV virion complexes.

公开(公告)号：EP2477658A2

公开(公告)日：2012-07-25

申请号：EP10817555.5

申请日：2010-09-16

申请人： Duke University ,  The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Feinstein Institute for Medical Research

发明人： HAYNES, Barton, F. ,  TOMARAS, Georgia ,  SHEN, Shaunna ,  DIMITROV, Dimiter, S. ,  ZHU, Zhongyu ,  HWANG, Kwan-Ki ,  CHIORAZZI, Nicholas

IPC分类号： A61K39/42 ,  C07K16/10 ,  C12N5/07 ,  A61P31/18

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

摘要： The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.

公开(公告)号：EP2539365A2

公开(公告)日：2013-01-02

申请号：EP11747821.4

申请日：2011-02-25

申请人： Duke University

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  TOMARAS, Georgia ,  KEPLER, Thomas, B. ,  HWANG, Kwan-Ki ,  ALAM, S., Munir ,  LIU, Yang ,  HOLL, T., Matt ,  YANG, Guang ,  KELSOE, Garnett ,  BONSIGNORI, Mattia

IPC分类号： C07K16/10 ,  C12N15/13 ,  A61K39/42 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/0005 ,  A61K39/0258 ,  A61K2039/53 ,  A61K2039/58 ,  C07K16/1063 ,  C12N2740/16034 ,  C12N2740/16134

摘要： The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.