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1.发明公开HIV-1-and HIV-2-peptides for inhibition of membranes fusion-associated events, including HIV transmission 失效方法和组合物的膜融合的抑制与相关现象，包括HIV的传输
公开(公告)号：EP1714974A3
公开(公告)日：2007-03-21
申请号：EP05077520.4
申请日：1995-12-20
申请人： Duke University , TRIMERIS INC.
发明人： Bolognesi, Dani P. , Matthews, Thomas J. , Wild, Cart T. , Barney, Shawn O'Lin , Lambert, Dennis M. , Pettewey, Stephen R., Jr. , Langlois, Alphonse J.
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
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2.发明公开HIV-1-and HIV-2-peptides for inhibition of membranes fusion-associated events, including HIV transmission 失效方法和组合物的膜融合的抑制与相关现象，包括HIV的传输
公开(公告)号：EP1714974A2
公开(公告)日：2006-10-25
申请号：EP05077520.4
申请日：1995-12-20
申请人： Duke University , TRIMERIS INC.
发明人： Bolognesi, Dani P. , Matthews, Thomas J. , Wild, Cart T. , Barney, Shawn O'Lin , Lambert, Dennis M. , Pettewey, Stephen R., Jr. , Langlois, Alphonse J.
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译： 本发明涉及一种显示出有效的抗逆转录病毒活性的肽。 本发明包括DP178的肽（SEQ ID：1）的肽对应于氨基酸638到HIV-1 gp41的LAI蛋白质673，和片段，类似物和DP178的同源物。 本发明还涉及到寻找肽作为人类和非人类逆转录病毒的抑制，爱特别是HIV，传输对未感染细胞的用途。
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公开(公告)号：EP1595890A3
公开(公告)日：2007-03-21
申请号：EP05007727.0
申请日：1994-06-07
申请人： Duke University
发明人： Bolognesi, Dani P. , Matthews, Thomas J. , Wild, Carl T. , Barney, Shaen O'Lin , Lambert, Dennis M. , Petteway, Stephen R. Jr.
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , C12N2710/16222 , C12N2730/10122 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , Y10S435/974 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID No:1) peptide corresponding to amino acids 638 to 673 of the HIV-1 LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
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4.发明公开Synthetic peptide inhibitors of HIV transmission 失效Synthetische Peptidinhibitoren der HIV-Übertragung
公开(公告)号：EP1595890A2
公开(公告)日：2005-11-16
申请号：EP05007727.0
申请日：1994-06-07
申请人： Duke University
发明人： Bolognesi, Dani P. , Matthews, Thomas J. , Wild, Carl T. , Barney, Shaen O'Lin , Lambert, Dennis M. , Petteway, Stephen R. Jr.
IPC分类号： C07K14/005 , A61K38/16 , C12N15/11 , C12N15/62 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , C12N2710/16222 , C12N2730/10122 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , Y10S435/974 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID No:1) peptide corresponding to amino acids 638 to 673 of the HIV-1 LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译： 本发明涉及显示出有力的抗逆转录病毒活性的肽。 本发明的肽包含对应于HIV-1 LAI gp41蛋白的氨基酸638至673的DP-178（SEQ ID No：1）肽以及DP-178的片段，类似物和同系物。 本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。
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