公开(公告)号：EP0446361A1

公开(公告)日：1991-09-18

申请号：EP90913246.6

申请日：1990-09-05

申请人： EARTH CHEMICAL CO., LTD.

发明人： SUGINAKA, Hidekazu ,  SUGAI, Motoyuki ,  HON, Yonman ,  OGAI, Hideo

IPC分类号： C07K14/00 ,  C12N15/12 ,  C12N15/62 ,  C12N1/21 ,  C12P21/02 ,  A61K38/00 ,  A61K7/00

CPC分类号： C12N9/2417 ,  A61K38/00 ,  C07K14/31 ,  C07K14/475 ,  C07K16/1271 ,  C12N15/75 ,  C12R1/445 ,  Y10S514/844 ,  Y10S514/969

摘要： The present invention relates to a polypeptide (CIF: Cornification Inhibiting Factor) characterized in that the polypeptide has a sequence of 212 amino acid residues and a molecular weight of about 24,000 daltons as determined by the SDS-PAGE, a process for preparing the polypeptide, pharmaceutical compositions and cosmetics comprising the polypeptide, and a method of preventing or curing symptoms of skin diseases due to abnormal cornification of the skin with use of the polypeptide.

摘要翻译： mol.wt.的一种新的多肽 24000（212个单位的氨基酸序列中给出）是obtd。 （即要求保护的）从DNA编码它。 此DNA被插入（优化连同一个信号序列）到合适的载体，并用于产生一个转化体上的快车多肽培养物（大肠杆菌或枯草芽孢杆菌的E. G.）。 特别要求保护的是枯草芽孢杆菌转化体IS182 FERM BP-3025，表达培养多肽。

公开(公告)号：EP0446361B1

公开(公告)日：1996-11-27

申请号：EP90913246.6

申请日：1990-09-05

申请人： EARTH CHEMICAL CO., LTD.

发明人： SUGINAKA, Hidekazu ,  SUGAI, Motoyuki ,  HON, Yonman ,  OGAI, Hideo

IPC分类号： C07K14/00 ,  C12N15/12 ,  C12N15/62 ,  C12N1/21 ,  C12P21/02 ,  A61K38/00 ,  A61K7/00

CPC分类号： C12N9/2417 ,  A61K38/00 ,  C07K14/31 ,  C07K14/475 ,  C07K16/1271 ,  C12N15/75 ,  C12R1/445 ,  Y10S514/844 ,  Y10S514/969

摘要： A cornification inhibiting factor, i.e. a polypeptide with a sequence of 212 amino acids and a molecular weight of about 24,000 daltons as determined by the SDS-PAGE technique, a method of producing said polypeptide, a pharmaceutical composition and cosmetic containing said polypeptide, and a method of preventing or treating skin diseases caused by cornification anomaly by using said polypeptide.