公开(公告)号：EP3099784A4

公开(公告)日：2017-07-05

申请号：EP15743189

申请日：2015-01-30

申请人： EASEL BIOTECHNOLOGIES LLC

发明人： HUO YI-XIN ,  SCHILLING BENJAMIN ,  RABIZADEH SHAHROOZ

IPC分类号： C12N1/21 ,  C12N9/10 ,  C12N15/63 ,  C12P1/02 ,  C12P5/02 ,  C12P7/16

CPC分类号： C12N9/88 ,  C10L1/00 ,  C10L2200/0469 ,  C10L2290/26 ,  C12N9/1205 ,  C12N15/74 ,  C12P5/026 ,  C12P7/16 ,  C12P7/625 ,  C12Y207/01019 ,  C12Y401/02009 ,  Y02E50/10

摘要： Genetically engineered cells and methods are presented that allow for the production of various value products from CO2. Contemplated cells have a CBB cycle that is genetically modified such that two molecules of CO2 fixed in the CBB cycle can be withdrawn from the modified CBB cycle as a single C2 compound. In contemplated aspects a CBB cycle includes an enzymatic activity that generates the single C2 compound from a compound of the CBB cycle, while further modifications to the CBB cycle will not introduce additional recombinant enzymatic activity/activities outside the already existing catalytic activities in the CBB cycle.

摘要翻译： 提出了基因工程细胞和方法，允许从二氧化碳生产各种有价值的产品。 考虑的细胞具有经过遗传修饰的CBB循环，使得在CBB循环中固定的两个CO 2分子可作为单一C2化合物从修饰的CBB循环中取出。 在考虑的方面，CBB循环包括从CBB循环的化合物产生单一C2化合物的酶活性，而对CBB循环的进一步修饰将不会在CBB循环中已有的催化活性外引入另外的重组酶活性/活性 。