PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF
    6.
    发明公开
    PREPARATION OF 4,5-DIAMINO-1-(SUBSTITUTED)-PYRAZOLE AND ACID ADDITION SALTS THEREOF 审中-公开
    制备4,5-二氨基-1-(取代)吡唑和酸加成盐从其

    公开(公告)号:EP1912950A2

    公开(公告)日:2008-04-23

    申请号:EP06813363.6

    申请日:2006-08-10

    IPC分类号: C07D231/38

    CPC分类号: C07D231/38

    摘要: Disclosed is an improved process for the preparation of 4,5-diamino- 1-(substituted)pyrazoles and acid addition salts thereof by coupling the corresponding 5-amino-1-(substituted)pyrazole with an aromatic diazonium compound to produce an intermediate azo compound and contacting the intermediate azo compound with hydrogen in the presence of a hydrogenation catalyst to produce 4,5-diamino-1-(substituted)pyrazoles. Also disclosed is a decarboxylation process for the preparation of a 5-amino-1-(substituted)pyrazole by heating a solution comprising a 5-amino-4-carboxy-1-(substituted)pyrazole, an inorganic acid and an inert solvent.