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1.发明授权SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代的烷基氨基哒嗪酮衍生物，其制备方法和含有该化合物的药物组合物
公开(公告)号：EP1430047B1
公开(公告)日：2005-02-09
申请号：EP02762620.9
申请日：2002-09-26
发明人： BARKOCZY, Júzsef , SIMIG, Gyula , KOTAY NAGY, Péter , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú, Gábor
IPC分类号： C07D401/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.
摘要翻译： 本发明涉及通式（I）的新的取代的烷基氨基哒嗪酮衍生物，其中R 1是氢或具有1-4个碳原子的烷基; X和Y中的一个代表氢或卤素，另一个代表通式 （II）中，R2是氢或具有1-4个碳原子的烷基; n是1,2或3; R3代表氢，具有1-4个碳原子的烷基或芳基 - （C1-4烷基）; Z代表氧 ;或者R3和Z与它们之间的基团一起形成哌嗪环; R4代表氢，卤素，三氟甲基或具有1-4个碳原子的烷氧基）及其药学上可接受的酸加成盐。 本发明化合物可用于治疗抗焦虑症和认知障碍。
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2.发明公开SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代ALKYLAMINOPYRIDAZINONDERIVATE，其制造方法SAME和药物制剂
公开(公告)号：EP1430047A1
公开(公告)日：2004-06-23
申请号：EP02762620.9
申请日：2002-09-26
发明人： BARKOCZY, Júzsef , SIMIG, Gyula , KOTAY NAGY, Péter , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú, Gábor
IPC分类号： C07D401/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.
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3.发明公开SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代的烷基氨基哒嗪酮衍生物，其制备方法和含有该化合物的药物组合物
公开(公告)号：EP1430034A1
公开(公告)日：2004-06-23
申请号：EP02767729.3
申请日：2002-09-26
发明人： BARK CZY, József , SIMIG, Gyula , KOTAY NAGY, Péter; , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka; , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú Gábor
IPC分类号： C07D237/22 , C07D401/12 , C07D403/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： New substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen or halogen; R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Q and W independently from each other stand for -N= or -CH=; and R4 and R5 independently from each other represent hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof possess useful anxiolytic and cognition enhancing properties.
摘要翻译： 通式（I）的新取代的烷基氨基哒嗪酮衍生物，其中R1是氢或具有1-4个碳原子的烷基; X是氢或卤素; R2是氢或具有1-4个碳原子的烷基; n是1,2或3。 3; Q和W彼此独立地代表-N =或-CH =;且R 4和R 5彼此独立地表示氢，卤素，三氟甲基或具有1-4个碳原子的烷氧基）及其药学上可接受的酸加成盐具有 有用的抗焦虑和认知增强特性。
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4.发明授权SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权取代ALKYLAMINOPYRIDAZINONDERIVATE，其制造方法SAME和药物制剂
公开(公告)号：EP1430034B1
公开(公告)日：2005-02-09
申请号：EP02767729.3
申请日：2002-09-26
发明人： BARKOCZY, Júzsef , SIMIG, Gyula , KOTAY NAGY, Péter; , LEVAY, György , GACSALYI, István , MARTONNE MARKO, Bernadett , SCHMIDT, Eva , EGYED, András , KOMPAGNE, Hajnalka; , LEVELEKI, Csilla , MIKLOSNE KOVACS, Anikú , SZENASI, Gábor , WELLMANN, János , HARSING, Lászlú Gábor
IPC分类号： C07D237/22 , C07D401/12 , C07D403/12 , A61K31/50 , A61P25/22 , A61P25/28
CPC分类号： C07D401/12 , C07D237/22 , C07D403/12 , C07D405/12
摘要： New substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen or halogen; R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Q and W independently from each other stand for -N= or -CH=; and R4 and R5 independently from each other represent hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof possess useful anxiolytic and cognition enhancing properties.
摘要翻译： X是氢或卤素; R 2是具有1-4个碳原子氢或烷基;通式（I），（其中R1为氢或具有1-4个碳原子烷基的新的取代衍生物alkylaminopyridazinone n是1，2或 3; Q和W相互独立地立场-N =或-CH =;和R4和R5彼此独立地代表氢，卤素，三氟甲基或烷氧基具有1-4个碳原子）和其药学上可接受的酸加成盐具有 有用的抗焦虑和认知增强性质。
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5.发明公开
公开(公告)号：EP1077973A2
公开(公告)日：2001-02-28
申请号：EP99923772.0
申请日：1999-05-13
发明人： AGAI, Béla , REITER, József , SIMIG, Gyula , RIVO, Endre , NAGY, Zoltán, Tamás , ONDI, Levente , IVANICSNE MEGYERI, Katalin , MIKLOSNE KOVACS, Anikú , NAGYNE GYÖNÖS, Ildikú , KERTESZ, Szabolcs , SZENASI, Gábor , SCHMIDT, Eva , PALLAGI, Katalin , GACSALYI, István , GYERTYAN, István , SZABADOS, Tamás , LEVAY, György; , EGYED, András
IPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , A61K31/34 , A61K31/44 , A61K31/505 , A61K31/38 , C07D307/83 , C07D307/86 , C07D407/12
CPC分类号： C07D307/79 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/14
摘要： The invention refers to novel benzofuran derivatives of formula (I), a process for preparing these compounds and to pharmaceutical compositions containing these active substances.
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