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1.发明授权A PROCESS FOR THE PREPARATION OF 2- 4-(ALPHA-PHENYL-P-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR 有权用于生产2- [4-（α-苯基-p-氯苄基）哌嗪-1-基] - 乙氧基及其中间体
公开(公告)号：EP1233954B1
公开(公告)日：2004-10-20
申请号：EP00981508.5
申请日：2000-11-29
发明人： REITER, József , TRINKA, Péter , BARTHA, Ferenc , SIMIG, Gyula , NAGY, Kálmán , VERECZKEYNE DONATH, Györgyi , NEMETH, Norbert; , CLEMENTIS, György; , TÖMPE, Péter , VAGO, Pál
IPC分类号： C07D295/088
CPC分类号： C07D295/088
摘要： The invention refers to a novel process for the preparation of cetirizine of formula (I) as well as to novel {2-[4-(α-phenyl-p-chloro-benzyl)piperazin-1-yl]ethoxy}acetamides of formula II, wherein R1 and R2 represent, independently, a C1-4 alkyl group optionally substituted by a phenyl group, a C2-4 alkenyl group or a cyclohexyl group, or R1 and R2 form together with the adjacent nitrogen atom a morpholino group. According to the novel process, an acetamide of formula (II) is hydrolized, if desired in the presence of a phase transfer catalyst, to obtain cetirizine.
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2.发明公开A PROCESS FOR THE PREPARATION OF 2- 4-(ALPHA-PHENYL-P-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR 有权用于生产2- [4-（α-苯基-p-氯苄基）哌嗪-1-基] - 乙氧基及其中间体
公开(公告)号：EP1233954A1
公开(公告)日：2002-08-28
申请号：EP00981508.5
申请日：2000-11-29
发明人： REITER, József , TRINKA, Péter , BARTHA, Ferenc , SIMIG, Gyula , NAGY, Kálmán , VERECZKEYNE DONATH, Györgyi , NEMETH, Norbert; , CLEMENTIS, György; , TÖMPE, Péter , VAGO, Pál
IPC分类号： C07D295/088
CPC分类号： C07D295/088
摘要： The invention refers to a novel process for the preparation of cetirizine of formula (I) as well as to novel {2-[4-(α-phenyl-p-chloro-benzyl)piperazin-1-yl]ethoxy}acetamides of formula II, wherein R1 and R2 represent, independently, a C1-4 alkyl group optionally substituted by a phenyl group, a C2-4 alkenyl group or a cyclohexyl group, or R1 and R2 form together with the adjacent nitrogen atom a morpholino group. According to the novel process, an acetamide of formula (II) is hydrolized, if desired in the presence of a phase transfer catalyst, to obtain cetirizine.
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3.发明公开
公开(公告)号：EP1077973A2
公开(公告)日：2001-02-28
申请号：EP99923772.0
申请日：1999-05-13
发明人： AGAI, Béla , REITER, József , SIMIG, Gyula , RIVO, Endre , NAGY, Zoltán, Tamás , ONDI, Levente , IVANICSNE MEGYERI, Katalin , MIKLOSNE KOVACS, Anikú , NAGYNE GYÖNÖS, Ildikú , KERTESZ, Szabolcs , SZENASI, Gábor , SCHMIDT, Eva , PALLAGI, Katalin , GACSALYI, István , GYERTYAN, István , SZABADOS, Tamás , LEVAY, György; , EGYED, András
IPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , A61K31/34 , A61K31/44 , A61K31/505 , A61K31/38 , C07D307/83 , C07D307/86 , C07D407/12
CPC分类号： C07D307/79 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/14
摘要： The invention refers to novel benzofuran derivatives of formula (I), a process for preparing these compounds and to pharmaceutical compositions containing these active substances.
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