公开(公告)号：EP0636368A1

公开(公告)日：1995-02-01

申请号：EP94111107.2

申请日：1994-07-18

申请人： EGIS GYOGYSZERGYAR RT.

发明人： Szirt, Eniko, geb. Kiszelly ,  Budai, Zoltan, Dr. ,  Mezei, Tibor, Dr.. ,  Blasko, Gabor, Dr. ,  Kazo, Klara, geb. Daroczi ,  Egyed, Andras, Dr. ,  Gigler, Gabor ,  Fekete, Marton, Dr. ,  Reiter, Klara, Dr. geb. Esses ,  Simig, Gyula, Dr. ,  Szemerédi, Katalin, Dr.

IPC分类号： A61K31/15 ,  A61K31/495

CPC分类号： A61K31/15 ,  A61K31/495

摘要： The subject-matter of the invention is the use of 2-[phenylmethylene]-1-[3'-(amino)-2'-(hydroxy)-propoxy-imino]-cyclohexane derviates of formula

wherein

R and R₁ independently mean hydrogen or halogen atom(s),
R o stands for hydrogen or a C₁₋₄ alkoxy group,
R₂ and R₃ independently represent hydrogen atom(s), straight and/or branched chain C₁₋₈ alkyl group(s), optionally substituted by a dimethylamino group, or C₂₋₆ alkenyl or C₃₋₇ cycloalkyl group(s) or
R₂ and R₃ together with the nitrogen atom to which they are attached form a 6-membered heterocyclic group containing an additional nitrogen atom, which latter optionally may bear a phenyl group, optionally substituted by a C₁₋₄ alkoxy group,
and their stereoisomers and optical isomers and mixtures thereof as well as pharmaceutically acceptable acid addition salts and quaternary ammonium derivatives thereof, optionally in admixture with 1 or more carrier(s) commonly used in pharmaceutical compositions, for preparing medicaments having gastroprotective and antimicrobial including antiulcer activity.

摘要翻译： 本发明的主题是使用式CHEM的2- [苯基亚甲基] -1- [3' - （氨基）-2' - （羟基） - 丙氧基 - 亚氨基] - 环己烷衍生物，其中R和R 1 独立地表示氢或卤素原子，Ro表示氢或C1-4烷氧基，R2和R3独立地表示氢原子，直链和/或支链C1-8烷基，任选取代的 二甲基氨基或C 2-6烯基或C 3-7环烷基或R 2和R 3与它们所连接的氮原子一起形成含有另外的氮原子的6元杂环基，后者任选地可以 承担任选被C 1-4烷氧基取代的苯基及其立体异构体和旋光异构体及其混合物，以及其药学上可接受的酸加成盐和季铵衍生物，任选与1种或多种载体混合 用于药物组合物，用于制备药物 胃肠保护和抗微生物剂，包括抗溃疡活性。