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    The use of 2- phenylmethylene -1- 3'-(amino)-2'-(hydroxy)--propoxy-imino -cyclohexane derivatives
    1.
    发明公开
    The use of 2- phenylmethylene -1- 3'-(amino)-2'-(hydroxy)--propoxy-imino -cyclohexane derivatives 失效
    Die Verwendung von 2-苯基亚甲基-1,3' - （氨基）-2-（羟基） - 丙氧基 - 亚氨基 - 环己烷 - 衍生物。

    公开(公告)号：EP0636368A1

    公开(公告)日：1995-02-01

    申请号：EP94111107.2

    申请日：1994-07-18

    申请人： EGIS GYOGYSZERGYAR RT.

    发明人： Szirt, Eniko, geb. Kiszelly ,  Budai, Zoltan, Dr. ,  Mezei, Tibor, Dr.. ,  Blasko, Gabor, Dr. ,  Kazo, Klara, geb. Daroczi ,  Egyed, Andras, Dr. ,  Gigler, Gabor ,  Fekete, Marton, Dr. ,  Reiter, Klara, Dr. geb. Esses ,  Simig, Gyula, Dr. ,  Szemerédi, Katalin, Dr.

    IPC分类号： A61K31/15 ,  A61K31/495

    CPC分类号： A61K31/15 ,  A61K31/495

    摘要： The subject-matter of the invention is the use of 2-[phenylmethylene]-1-[3'-(amino)-2'-(hydroxy)-propoxy-imino]-cyclohexane derviates of formula

    wherein

    R and R₁ independently mean hydrogen or halogen atom(s),
    R o stands for hydrogen or a C₁₋₄ alkoxy group,
    R₂ and R₃ independently represent hydrogen atom(s), straight and/or branched chain C₁₋₈ alkyl group(s), optionally substituted by a dimethylamino group, or C₂₋₆ alkenyl or C₃₋₇ cycloalkyl group(s) or
    R₂ and R₃ together with the nitrogen atom to which they are attached form a 6-membered heterocyclic group containing an additional nitrogen atom, which latter optionally may bear a phenyl group, optionally substituted by a C₁₋₄ alkoxy group,
    and their stereoisomers and optical isomers and mixtures thereof as well as pharmaceutically acceptable acid addition salts and quaternary ammonium derivatives thereof, optionally in admixture with 1 or more carrier(s) commonly used in pharmaceutical compositions, for preparing medicaments having gastroprotective and antimicrobial including antiulcer activity.

    摘要翻译： 本发明的主题是使用式CHEM的2- [苯基亚甲基] -1- [3' - （氨基）-2' - （羟基） - 丙氧基 - 亚氨基] - 环己烷衍生物，其中R和R 1 独立地表示氢或卤素原子，Ro表示氢或C1-4烷氧基，R2和R3独立地表示氢原子，直链和/或支链C1-8烷基，任选取代的 二甲基氨基或C 2-6烯基或C 3-7环烷基或R 2和R 3与它们所连接的氮原子一起形成含有另外的氮原子的6元杂环基，后者任选地可以 承担任选被C 1-4烷氧基取代的苯基及其立体异构体和旋光异构体及其混合物，以及其药学上可接受的酸加成盐和季铵衍生物，任选与1种或多种载体混合 用于药物组合物，用于制备药物 胃肠保护和抗微生物剂，包括抗溃疡活性。

    Benz[e]indene derivatives and a process for preparing them as well as medicaments containing them and the use of them
    4.
    发明公开
    Benz[e]indene derivatives and a process for preparing them as well as medicaments containing them and the use of them 失效
    苯并[e]茚衍生物，它们的制备方法和含有它们的药物组合物和它们的用途。

    公开(公告)号：EP0595364A1

    公开(公告)日：1994-05-04

    申请号：EP93117721.6

    申请日：1993-11-02

    申请人： EGIS GYOGYSZERGYAR RT.

    发明人： Reiter née Eszes, Klàra ,  Budai, Zoltan, Dr. ,  Mezei, Tibor, Dr. ,  Blaskò, Gàbor, Dr. ,  Simig, Gyula, Dr. ,  Gyertyàn, Istvàn Dr.

    IPC分类号： C07C251/58 ,  C07C271/60 ,  C07D295/08 ,  C07D213/74 ,  C07D239/34 ,  C07D303/12

    CPC分类号： C07D209/48 ,  C07C251/58 ,  C07C271/60 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/16 ,  C07D213/74 ,  C07D239/34 ,  C07D295/088 ,  C07D303/12

    摘要： A subject-matter of the invention are benz[e]indene derivatives of the generel formula

    wherein

    A represents a group of the formula
    in which latter
    alk means a C₂₋₇ alkylene group, optionally substituted by a hydroxy group and
    R₁ and R₂ stand independently for hydrogen or a C₁₋₇ alkyl, C₂₋₇ alkenyl, C₂₋₇ alkynyl, C₃₋₇ cycloalkyl, mono-(C₁₋₇)alkylamino-(C₁₋₇)alkyl or di-(C₁₋₇)alkylamino-(C₁₋₇)alkyl group or
    R₁ and R₂ together with the nitrogen atom to which they are attached form a 4 to 7 membered heterocyclic ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may be substituted by a phenyl, benzyl, pyridyl, pyrimidinyl or C₁₋₃ alkyl group which latter ones, in turn, may be substituted by a hydroxy or methoxy group or a halogen atom or a halophenyl group or
    R₁ and R₂ together with the nitrogen atom to which they are attached form a phthalimido group or
    A means a pyrimidino group, a 2,3-(epoxy)-propyl group or a group of the formula
    in which latter
    R₃ stands for a C₁₋₇ alkyl, C₂₋₇ alkenyl or C₃₋₈ cycloalkyl group and
    R denotes hydrogen or a C₁₋₇ alkyl group,
    and their stereoisomers and optically active isomers and mixtures thereof, as well as acid addition salts and quaternary ammonium derivatives of these compounds.
    Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds.

    摘要翻译： 本发明的主题是generel式苯并[e]茚衍生物 worin甲darstellt下式基团在后一种ALK指C 2-7亚烷基氧基，任选被羟基substituiertem R1和R2代表独立地为氢或C 1-7烷基，C 2-7烯基，C 2-7炔基，C 3-7环烷基，单 - （C 1-7）烷基氨基（C 1-7）烷基或二 - （C1 -7）烷基氨基（C 1-7）烷基或R1和R2一起与氮原子到它们所连接形成4至7元杂环，其任选地包含氧原子或氮原子。此外，后一种可能是 通过下文的一些，反过来，可以由羟基或甲氧基或卤原子或卤代苯基，或R 1和R 2一起与氮原子来取代的苯基，苄基，吡啶基，嘧啶基或C 1-3烷基substituiertem 它们所连接形式苯二甲酰基基团或一种手段pyrimidinio基，2,3-（环氧） - 丙基组或下式基团的 后一种R 3代表一个C 1-7烷基，C 2-7链烯基或C 3-8环烷基和R表示氢或C 1-7烷基，和它们的立体异构体和光学活性异构体及其混合物，以及酸加成盐 化合物论文和季铵衍生物。 更上方设置有用于制备合成的化合物，药物含有它们和使用合成的化合物的方法。