公开(公告)号：EP0831094A4

公开(公告)日：2001-11-21

申请号：EP96920027

申请日：1996-05-31

申请人： EISAI CO LTD

发明人： SUGUMI HIROYUKI ,  NIIJIMA JUN ,  KOTAKE YOSHIHIKO ,  OKADA TOSHIMI ,  KAMATA JUN-ICHI ,  YOSHIMATSU KENTARO ,  NAGASU TAKESHI ,  NAKAMURA KATSUJI ,  UENAKA TOSHIMITSU ,  YAMAGUCHI ATSUMI ,  YOSHINO HIROSHI ,  KOYANAGI NOZOMU ,  KITO KYOSUKE

IPC分类号： C07D471/06 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D491/16 ,  C07D495/16 ,  C07D498/06 ,  C07D513/06 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54

CPC分类号： C07D471/06 ,  C07D487/06 ,  C07D513/06

摘要： Novel fused polycyclic heterocycle derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which have an excellent antitumor effect, and a process for producing the same, wherein the ring A represents an optionally substituted monocyclic aromatic ring or a fused bicyclic ring wherein at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-dioxane, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted monocyclic or fused bicyclic aromatic ring; and Y represents -e-f (wherein e represents lower alkylene; and f represents amidino, guanidino, or amino optionally substituted by hydroxy or lower alkyl optionally lower-alkylaminated); excluding a combination wherein the rings A and C are each an optionally substituted monocyclic aromatic ring.