公开(公告)号：EP0673937A4

公开(公告)日：1996-01-17

申请号：EP94926372

申请日：1994-09-08

申请人： EISAI CO LTD

发明人： YOSHINO HIROSHI ,  OWA TAKASHI ,  OKAUCHI TATSUO ,  YOSHIMATSU KENTARO ,  SUGI NAOKO ,  NAGASU TAKESHI ,  OZAWA YOICHI ,  KOYANAGI NOZOMU ,  KITO KYOSUKE

IPC分类号： C07D209/14 ,  A61K31/40 ,  A61K31/404 ,  A61K31/635 ,  A61P35/00 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  A61K31/415 ,  A61K31/435

CPC分类号： C07D401/12 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D231/56 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04

摘要： Novel bicyclic heterocyclic sulfonamide and sulfonic ester derivatives represented by general formula (I) having an antitumor activity and a reduced toxicity, pharmacologically acceptable salts thereof, and a process for producing the same; wherein ring A represents an optionally substituted mono- or bicyclic aromatic group; ring B represents an optionally substituted 6-membered unsaturated hydrocarbon ring or 6-membered unsaturated heterocyclic group containing one nitrogen atom; ring C represents an optionally substituted 5-membered heterocyclic group containing one or two nitrogen atoms; W represents a single bond or -CH=CH-; X represents -NR1- or oxygen; Y represents carbon or nitrogen; Z represents -NR2- or nitrogen; and R?1 and R2¿ represent each independently hydrogen or lower alkyl.

公开(公告)号：EP0679641A4

公开(公告)日：1996-03-20

申请号：EP94921819

申请日：1994-07-26

申请人： EISAI CO LTD

发明人： YOSHINO HIROSHI ,  UEDA NORIHIRO ,  NIIJIMA JUN ,  HANEDA TORU ,  KOTAKE YOSHIHIKO ,  YOSHIMATSU KENTARO ,  WATANABE TATSUO ,  NAGASU TAKESHI ,  TSUKAHARA NAOKO ,  KOYANAGI NOZOMU ,  KITO KYOSUKE

IPC分类号： C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/04 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D498/04 ,  C07D513/04 ,  C07F7/18 ,  C07D241/46 ,  C07D253/06 ,  C07D279/14

CPC分类号： C07D219/04 ,  C07C211/55 ,  C07C229/58 ,  C07C311/29 ,  C07D209/88 ,  C07D219/06 ,  C07D219/08 ,  C07D221/12 ,  C07D223/22 ,  C07D243/38 ,  C07D265/38 ,  C07D267/18 ,  C07D267/20 ,  C07D279/20 ,  C07D281/14 ,  C07D413/12 ,  C07D513/04 ,  C07F7/1856

摘要： Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents O or NR1, wherein R1 represents hydrogen or lower alkyl; and M represents a tricyclic structure selected from the members (a), (b), (c), (d), (e), (f), wherein rings A and B represent each a 5- or 6-membered unsaturated ring; X represents NR2 (wherein R2 represents hydrogen or lower alkyl) or NHCO; Y represents O, S(O)¿n?, CR?3R4¿, CO, NR?5, CHR6CHR7, CR8=CR9, NR10¿CO, N=CR?11, OCHR12¿, S(O)¿n?CHR?13 or NR14CHR15¿; and Z represents N or CR16, wherein n represents 0, 1 or 2; R?3-R13, R15 and R16¿ represent each hydrogen or lower alkyl; and R14 represents hydrogen, lower alkyl or lower acyl.

公开(公告)号：EP1433479A4

公开(公告)日：2005-07-13

申请号：EP02767898

申请日：2002-09-05

申请人： EISAI CO LTD

发明人： OWA TAKASHI ,  OZAWA YOICHI ,  HIDA TAKAYUKI ,  MIYAMOTO NORIMASA ,  NAGASU TAKESHI ,  OKAUCHI TATSUO ,  YOSHINO HIROSHI ,  HATA NAOKO ,  YOSHIMATSU KENTARO ,  KOYANAGI NOZOMU ,  KITO KYOSUKE

IPC分类号： A23L1/30 ,  A61K31/4035 ,  A61P1/14 ,  A61P35/00 ,  A61P43/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/4439 ,  A61K45/00 ,  C07D231/56

CPC分类号： C07D401/12 ,  A23L33/10 ,  A61K31/4035 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04

摘要： Appetite-stimulating agents containing as the active ingredient sulfonamide or sulfonic ester derivatives represented by the general formula (I), pharmacologically acceptable salts thereof, or hydrates of both: (I) wherein A is an optionally substituted mono- or bi-cyclic aromatic ring; B is an optionally substituted six-membered unsaturated hydrocarbon ring or an unsaturated six-membered heterocycle containing one nitrogen atom; C is an optionally substituted five-membered heterocycle containing one or two nitrogen atoms; W is a single bond or -CH=CH-; X is -N(R1)- or oxygen; Y is carbon or nitrogen; Z is -N(R2)- or nitrogen; and R1 and R2 are each independently hydrogen or lower alkyl.

公开(公告)号：EP0831094A4

公开(公告)日：2001-11-21

申请号：EP96920027

申请日：1996-05-31

申请人： EISAI CO LTD

发明人： SUGUMI HIROYUKI ,  NIIJIMA JUN ,  KOTAKE YOSHIHIKO ,  OKADA TOSHIMI ,  KAMATA JUN-ICHI ,  YOSHIMATSU KENTARO ,  NAGASU TAKESHI ,  NAKAMURA KATSUJI ,  UENAKA TOSHIMITSU ,  YAMAGUCHI ATSUMI ,  YOSHINO HIROSHI ,  KOYANAGI NOZOMU ,  KITO KYOSUKE

IPC分类号： C07D471/06 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D491/16 ,  C07D495/16 ,  C07D498/06 ,  C07D513/06 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54

CPC分类号： C07D471/06 ,  C07D487/06 ,  C07D513/06

摘要： Novel fused polycyclic heterocycle derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which have an excellent antitumor effect, and a process for producing the same, wherein the ring A represents an optionally substituted monocyclic aromatic ring or a fused bicyclic ring wherein at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-dioxane, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted monocyclic or fused bicyclic aromatic ring; and Y represents -e-f (wherein e represents lower alkylene; and f represents amidino, guanidino, or amino optionally substituted by hydroxy or lower alkyl optionally lower-alkylaminated); excluding a combination wherein the rings A and C are each an optionally substituted monocyclic aromatic ring.