公开(公告)号：EP1057819A4

公开(公告)日：2003-02-05

申请号：EP99905213

申请日：1999-02-17

申请人： EISAI CO LTD

发明人： WATANABE NOBUHISA ,  KARIBE NORIO ,  MIYAZAKI KAZUKI ,  OZAKI FUMIHIRO ,  KAMADA ATSUSHI ,  MIYAZAWA SHUHEI ,  NAOE YOSHIMITSU ,  KANEKO TOSHIHIKO ,  TSUKADA ITARU ,  NAGAKURA TADASHI ,  ISHIHARA HIROKI ,  KODAMA KOHTAROU ,  ADACHI HIDEYUKI

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P15/00 ,  A61P15/10 ,  C07D237/28 ,  C07D237/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/08 ,  C07D521/00 ,  C07D451/02

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D237/28 ,  C07D237/34 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/14 ,  C07D417/04 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D491/04 ,  C07D491/08 ,  C07D491/10

摘要： Phthalazine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof or hydrates of the same usable as remedies for erectile dysfunction, wherein R1 and R2 are the same or different and each represents halogeno, optionally halogenated alkyl or alkoxy, or cyano; X represents cyano, nitro, halogeno, optionally substituted hydroxyimino or optionally substituted heteroaryl; and Y represents heteroaryl, aryl, alkynyl, alkenyl, alkyl or cyclic amine.