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1.发明授权Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method 无效一种用于与Stopsmoking断奶症状以及剂用于本方法相关联的处理方法
公开(公告)号：EP0289342B1
公开(公告)日：1998-01-07
申请号：EP88303918.2
申请日：1988-04-29
发明人： Bannon, Yvonne Brigid , Corish, John , Corrigan, Owen Ignatius , Geoghegan, Edward James , Masterson, Joseph G.
IPC分类号： A61K31/465 , A61K47/00 , A61L15/00
CPC分类号： A61K9/7069 , A61K9/7023 , A61K9/7084 , A61K31/465 , A61K47/34 , A61K47/36 , A61K47/42 , Y10S514/813 , Y10S514/922 , Y10S514/936 , Y10S514/944 , Y10S514/946 , Y10S514/964 , Y10S514/965 , Y10S514/974
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2.发明公开Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method 无效一种用于与Stopsmoking断奶症状，以及用于在该方法中使用试剂有关的处理方法。
公开(公告)号：EP0289342A2
公开(公告)日：1988-11-02
申请号：EP88303918.2
申请日：1988-04-29
发明人： Bannon, Yvonne Brigid , Corish, John , Corrigan, Owen Ignatius , Geoghegan, Edward James , Masterson, Joseph G.
IPC分类号： A61K31/465 , A61K47/00 , A61L15/00
CPC分类号： A61K9/7069 , A61K9/7023 , A61K9/7084 , A61K31/465 , A61K47/34 , A61K47/36 , A61K47/42 , Y10S514/813 , Y10S514/922 , Y10S514/936 , Y10S514/944 , Y10S514/946 , Y10S514/964 , Y10S514/965 , Y10S514/974
摘要： A preparation for the once-daily, percutaneous administration of nicotine comprises nicotine uniformly distributed in a solid, semi-solid or mucilaginous medium which can be placed in intimate contact with the skin, the solid, semi-solid or mucilaginous medium is formed by adding a given amount of nicotine to a solution of a solidifying or gel-forming agent or mixture thereof in a suitable solvent or mixture of solvents and mixing or heating the mixture thereby obtained so as to form the solid, semi-solid or mucilaginous medium.
The preparation can be used in a method of treating withdrawal symptoms associated with smoking cessation and for combating the psychological dependence that occurs through frequent smoking.摘要翻译： 一种用于烟碱的每日一次，经皮给药制剂包括烟碱均匀地分布在可以在与皮肤紧密接触被放置在固体，半固体或粘液介质，固体，半固体或粘液介质通过添加FORMED 尼古丁到凝固或溶液的给定量的凝胶形成中溶剂的合适的溶剂或它们的混合物剂或混合物和混合或加热该混合物由此获得以形成固体，半固体或粘液平台。 该制剂可以治疗与戒烟有关的戒断症状的方法，并打击了依赖心理被用来做了发生通过频繁的吸烟。
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公开(公告)号：EP0252732A3
公开(公告)日：1989-03-22
申请号：EP87306033.9
申请日：1987-07-08
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325
摘要： A disposable electrode (3) for use in a transdermal device comprises a first surface adapted for contact with human skin and through which a drug substance contained in the electrode passes to the skin under the influence of an iontophoretic or electro-osmotic force and a second surface (4) which is electrically conducting, the electrode has a surface area in contact with the skin, in use, in the range 0.1 to 30 cm² and a drug dissolved or dispersed in a hydrophilic medium (5) at a concentration in the range 0.1 to 15% (w/v) based on the hydrophilic medium.
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4.发明公开Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method 无效用于治疗与吸烟消化相关的抽搐症状的方法和用于治疗方法的制剂
公开(公告)号：EP0289342A3
公开(公告)日：1989-01-25
申请号：EP88303918.2
申请日：1988-04-29
发明人： Bannon, Yvonne Brigid , Corish, John , Corrigan, Owen Ignatius , Geoghegan, Edward James , Masterson, Joseph G.
IPC分类号： A61K31/465 , A61K47/00 , A61L15/00
CPC分类号： A61K9/7069 , A61K9/7023 , A61K9/7084 , A61K31/465 , A61K47/34 , A61K47/36 , A61K47/42 , Y10S514/813 , Y10S514/922 , Y10S514/936 , Y10S514/944 , Y10S514/946 , Y10S514/964 , Y10S514/965 , Y10S514/974
摘要： A preparation for the once-daily, percutaneous administration of nicotine comprises nicotine uniformly distributed in a solid, semi-solid or mucilaginous medium which can be placed in intimate contact with the skin, the solid, semi-solid or mucilaginous medium is formed by adding a given amount of nicotine to a solution of a solidifying or gel-forming agent or mixture thereof in a suitable solvent or mixture of solvents and mixing or heating the mixture thereby obtained so as to form the solid, semi-solid or mucilaginous medium. The preparation can be used in a method of treating withdrawal symptoms associated with smoking cessation and for combating the psychological dependence that occurs through frequent smoking.
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公开(公告)号：EP0252732B1
公开(公告)日：1994-02-09
申请号：EP87306033.9
申请日：1987-07-08
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325
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6.发明公开
公开(公告)号：EP0252732A2
公开(公告)日：1988-01-13
申请号：EP87306033.9
申请日：1987-07-08
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325
摘要： A disposable electrode (3) for use in a transdermal device comprises a first surface adapted for contact with human skin and through which a drug substance contained in the electrode passes to the skin under the influence of an iontophoretic or electro-osmotic force and a second surface (4) which is electrically conducting, the electrode has a surface area in contact with the skin, in use, in the range 0.1 to 30 cm² and a drug dissolved or dispersed in a hydrophilic medium (5) at a concentration in the range 0.1 to 15% (w/v) based on the hydrophilic medium.
摘要翻译： 用于透皮装置的一次性电极（3）包括适于与人体皮肤接触的第一表面，并且电极中含有的药物通过该电极在离子电渗或电渗透的作用下通过皮肤，而第二表面 导电的表面（4），电极在使用中具有与皮肤接触的表面积，范围为0.1至30cm 2，并且以浓度溶解或分散在亲水介质（5）中的药物 在基于亲水介质的0.1至15％（w / v）的范围内。
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