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1.发明授权2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS 有权2- [4-（吡唑-4-基） - 哌嗪-1-基] -3-苯基]吡啶-3-基] -3- [4-（吡唑-4-基） - 哌嗪-1-基] -2 - [ - 苯基 - 吡啶ALS 5-HT7-REZEPTORANTAGONISTEN
公开(公告)号：EP2155717B1
公开(公告)日：2012-10-24
申请号：EP08747748.5
申请日：2008-05-07
发明人： BADESCU, Valentina, O. , CAMP, Anne, Marie , CLARK, Barry, Peter , COHEN, Michael, Philip , FILLA, Sandra, Ann , GALLAGHER, Peter, Thaddeus , HELLMAN, Sarah, Lynne , MAZANETZ, Michael, Philip , PINEIRO-NUNEZ, Marta, Maria , SCHAUS, John, Mehnert , SPINAZZE, Patrick, Gianpietro , WHATTON, Maria, Ann
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/497 , A61P25/00
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2201002B1
公开(公告)日：2012-03-07
申请号：EP08836911.1
申请日：2008-09-30
IPC分类号： C07D401/14 , C07D403/12 , A61K31/497 , A61P25/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is C(H)= or -N= and R1-7 are as defined herein.
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公开(公告)号：EP2201002A1
公开(公告)日：2010-06-30
申请号：EP08836911.1
申请日：2008-09-30
IPC分类号： C07D401/14 , C07D403/12 , A61K31/497 , A61P25/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is C(H)= or -N= and R1-7 are as defined herein.
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4.发明公开2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS 有权2- [4-（吡唑-4-基YLALKYL-基）哌嗪-1-基] -3-苯基 - 吡嗪和AND - 吡啶3- [4-（吡唑-4-基YLALKYL-）哌嗪-1-基] -2- 苯基吡啶作为5HT 7受体拮抗剂
公开(公告)号：EP2155717A1
公开(公告)日：2010-02-24
申请号：EP08747748.5
申请日：2008-05-07
发明人： BADESCU, Valentina, O. , CAMP, Anne, Marie , CLARK, Barry, Peter , COHEN, Michael, Philip , FILLA, Sandra, Ann , GALLAGHER, Peter, Thaddeus , HELLMAN, Sarah, Lynne , MAZANETZ, Michael, Philip , PINEIRO-NUNEZ, Marta, Maria , SCHAUS, John, Mehnert , SPINAZZE, Patrick, Gianpietro , WHATTON, Maria, Ann
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/497 , A61P25/00
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.
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