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1.发明授权2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS 有权2- [4-（吡唑-4-基） - 哌嗪-1-基] -3-苯基]吡啶-3-基] -3- [4-（吡唑-4-基） - 哌嗪-1-基] -2 - [ - 苯基 - 吡啶ALS 5-HT7-REZEPTORANTAGONISTEN
公开(公告)号：EP2155717B1
公开(公告)日：2012-10-24
申请号：EP08747748.5
申请日：2008-05-07
发明人： BADESCU, Valentina, O. , CAMP, Anne, Marie , CLARK, Barry, Peter , COHEN, Michael, Philip , FILLA, Sandra, Ann , GALLAGHER, Peter, Thaddeus , HELLMAN, Sarah, Lynne , MAZANETZ, Michael, Philip , PINEIRO-NUNEZ, Marta, Maria , SCHAUS, John, Mehnert , SPINAZZE, Patrick, Gianpietro , WHATTON, Maria, Ann
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/497 , A61P25/00
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
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2.发明公开USE OF N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES AS SELECTIVE MGLUR1 ANTAGONISTS 审中-公开使用N-取代的（3,6-二氢）-2H-1,2-恶嗪衍生物作为选择性拮抗剂mGluR1的
公开(公告)号：EP1124806A2
公开(公告)日：2001-08-22
申请号：EP99952687.4
申请日：1999-11-01
IPC分类号： C07D265/02 , A61K31/535 , A61P25/00
CPC分类号： C07D265/02
摘要： Use of a compound of formula (I) in which, R?1, R2 and R3¿ are independently hydrogen, (C¿1?-C6)alkyl, (C2-C6)alkenyl, (C3-C10)cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl(C1-C6)alkyl, unsubstituted or substituted aryl(c2-C6)alkenyl, halo, carboxy, (C1-C6)alkoxycarbonyl or -(CH2)m-OH wherein m is 1, 2 or 3; --- indicates a single or a double bond; X and Y are each independently hydrogen, or X and Y together represent a bridge of the formula -(CH2)n-, where n is 1 or 2; A1 and A2 are each independently an unsubstituted or substituted aryl; Z is -CO-, -SO2- or -CH2-; provided that, when Z is -CO-, A1 is not 3,4,5-trimethoxyphenyl; or a pharmaceutically-acceptable salt or ester thereof, for the manufacture of a medicament for the treatment of a condition indicating the administration of a selective mGluR1 antagonist.
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3.发明授权4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS 有权4- AMINOPIPERIDINDERIVATE AS MONO AMIN记录抑制剂
公开(公告)号：EP1735302B1
公开(公告)日：2010-06-16
申请号：EP05722890.0
申请日：2005-02-11
发明人： BOULET, Serge, Louis , CLARK, Barry, Peter , FAIRHURST, John , GALLAGHER, Peter, Thaddeus , JOHANSSON, Anette, Margareta , WHATTON, Maria, Ann , WOOD, Virginia, Ann
IPC分类号： C07D409/12 , C07D405/12 , C07D401/12 , C07D417/12 , C07D513/04 , A61K31/435 , A61P25/00
CPC分类号： C07D513/04 , A61K31/454 , A61K31/4545 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.
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4.发明公开2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS 有权2- [4-（吡唑-4-基YLALKYL-基）哌嗪-1-基] -3-苯基 - 吡嗪和AND - 吡啶3- [4-（吡唑-4-基YLALKYL-）哌嗪-1-基] -2- 苯基吡啶作为5HT 7受体拮抗剂
公开(公告)号：EP2155717A1
公开(公告)日：2010-02-24
申请号：EP08747748.5
申请日：2008-05-07
发明人： BADESCU, Valentina, O. , CAMP, Anne, Marie , CLARK, Barry, Peter , COHEN, Michael, Philip , FILLA, Sandra, Ann , GALLAGHER, Peter, Thaddeus , HELLMAN, Sarah, Lynne , MAZANETZ, Michael, Philip , PINEIRO-NUNEZ, Marta, Maria , SCHAUS, John, Mehnert , SPINAZZE, Patrick, Gianpietro , WHATTON, Maria, Ann
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/497 , A61P25/00
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.
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公开(公告)号：EP1735302A1
公开(公告)日：2006-12-27
申请号：EP05722890.0
申请日：2005-02-11
发明人： BOULET, Serge, Louis , CLARK, Barry, Peter , FAIRHURST, John , GALLAGHER, Peter, Thaddeus , JOHANSSON, Anette, Margareta , WHATTON, Maria, Ann , WOOD, Virginia, Ann
IPC分类号： C07D409/12 , C07D405/12 , C07D401/12 , C07D417/12 , C07D513/04 , A61K31/435 , A61P25/00
CPC分类号： C07D513/04 , A61K31/454 , A61K31/4545 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.
摘要翻译： 本发明提供了式（I）的化合物，其中n，R 1，R 2，R 3，R 4，R 5和杂芳基如本文所定义。 所述化合物是一种或多种选自5-羟色胺，去甲肾上腺素和多巴胺的单胺的摄取抑制剂，因此可用于治疗中枢和/或外周神经系统的病症。
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