公开(公告)号：EP2552471A1

公开(公告)日：2013-02-06

申请号：EP11711424.9

申请日：2011-03-23

申请人： ELI LILLY AND COMPANY

发明人： ALSINA-FERNANDEZ, Jorge ,  BOKVIST, Krister Bengt ,  GUO, Lili ,  MAYER, John Philip

IPC分类号： A61K38/16 ,  C07K14/47 ,  C07K14/62 ,  A61K38/30 ,  A61K38/26 ,  C07K14/605

CPC分类号： C07K14/605 ,  A61K38/00 ,  C07K14/723

摘要： The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like peptide- 1 receptor (GLP-1-R) and are selective over glucagon receptor (Gluc-R). Specifically provided are GIP analogs with amino acid substitutions introduced to modulate activity for both GIP-R and GLP-1-R and maintain selectivity over Gluc-R.

公开(公告)号：EP2552471B1

公开(公告)日：2016-03-16

申请号：EP11711424.9

申请日：2011-03-23

申请人： ELI LILLY AND COMPANY

发明人： ALSINA-FERNANDEZ, Jorge ,  BOKVIST, Krister Bengt ,  GUO, Lili ,  MAYER, John Philip

IPC分类号： A61K38/16 ,  C07K14/47 ,  C07K14/62 ,  A61K38/30 ,  A61K38/26 ,  C07K14/605

CPC分类号： C07K14/605 ,  A61K38/00 ,  C07K14/723