公开(公告)号：EP1483265B1

公开(公告)日：2006-11-22

申请号：EP03711146.5

申请日：2003-03-04

申请人： ELI LILLY AND COMPANY

发明人： CLAYTON, Joshua, Ryan ,  DIEFENBACHER, Clive, Gideon ,  ENGLER, Thomas, Albert ,  FURNESS, Kelly, Wayne ,  HENRY, James, Robert ,  MALHOTRA, Sushant ,  MARQUART, Angela, Lynn ,  MCLEAN, Johnathan, Alexander ,  MENDEL, David ,  BURKHOLDER, Timothy, Paul ,  LI, Yihong ,  REEL, Jon, Kevin ,  SULLIVAN, John Morris ,  BERRIDGE, Brian Raymond ,  RUEGG, Charles Edward

IPC分类号： C07D487/06 ,  A61P25/08

CPC分类号： C07D471/06 ,  C07D487/06

摘要： The present invention provides kinase inhibitors of Formula I.

公开(公告)号：EP1812450A2

公开(公告)日：2007-08-01

申请号：EP05815629.0

申请日：2005-11-02

申请人： ELI LILLY AND COMPANY

发明人： DIEFENBACHER, Clive, Gideon ,  ENGLER, Thomas, Albert ,  LI, Hong-yu ,  MALHOTRA, Sushant ,  SAWYER, Jason, Scott ,  WANG, Yan

IPC分类号： C07D519/00 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： The present invention is directed to inhibitors of TGF-BETA of Formula (I).

公开(公告)号：EP1567527A1

公开(公告)日：2005-08-31

申请号：EP03783318.3

申请日：2003-11-24

申请人： ELI LILLY AND COMPANY

发明人： BEIGHT, Douglas, Wade ,  BURKHOLDER, Timothy, Paul ,  DECOLLO, Todd, Vincent ,  GODFREY, Alexander, Glenn ,  HEAP, Charles, Raymond ,  KING, Chi-Hsin, Richard ,  LI, Hong-Yu ,  MCMILLEN, William, Thomas ,  SAWYER, Jason, Scott ,  WANG, Yan ,  DIEFENBACHER, Clive, Gideon ,  ENGLER, Thomas, Albert ,  MALHOTRA, Sushant ,  MUNDLA, Sreenivasa, Reedy

IPC分类号： C07D487/04 ,  A61K31/4162 ,  A61P35/00 ,  C07D519/00

CPC分类号： C07D487/04

摘要： The current invention relates to compounds of the formula:(Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.

公开(公告)号：EP1483265A1

公开(公告)日：2004-12-08

申请号：EP03711146.5

申请日：2003-03-04

申请人： ELI LILLY AND COMPANY

发明人： CLAYTON, Joshua, Ryan ,  DIEFENBACHER, Clive, Gideon ,  ENGLER, Thomas, Albert ,  FURNESS, Kelly, Wayne ,  HENRY, James, Robert ,  MALHOTRA, Sushant ,  MARQUART, Angela, Lynn ,  MCLEAN, Johnathan, Alexander ,  MENDEL, David ,  BURKHOLDER, Timothy, Paul ,  LI, Yihong ,  REEL, Jon, Kevin ,  SULLIVAN, John Morris ,  BERRIDGE, Brian Raymond ,  RUEGG, Charles Edward

IPC分类号： C07D487/06 ,  A61P25/08

CPC分类号： C07D471/06 ,  C07D487/06

摘要： The present invention provides kinase inhibitors of Formula I.