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公开(公告)号：EP1149085A1
公开(公告)日：2001-10-31
申请号：EP00904438.9
申请日：2000-01-19
发明人： BRINER, Karin , BURKHART, Joseph, Paul , BURKHOLDER, Timothy, Paul , FISHER, Matthew, Joseph , GRITTON, William, Harlan , KOHLMAN, Daniel, Timothy , LIANG, Sidney, Xi , MILLER, Shawn, Christopher , MULLANEY, Jeffrey, Thomas , XU, Yao-Chang , XU, Yanping
IPC分类号： C07D307/81 , C07D307/82 , C07D307/84 , C07D307/85 , C07F7/10 , C07D407/12 , A61K31/34 , A61P3/04
CPC分类号： C07D307/79 , C07F7/0814
摘要： The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R?1, R2, R3, R4, R4', R5, R5¿', and R12 are as described in the specification.
摘要翻译： 本发明提供了式（I）的5-羟色胺能氨基烷基苯并呋喃：其中R，R 1，R 2，R 3，R 4，R 4'，R 5，R 5'和R 12如说明书中所述。
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公开(公告)号：EP2491032A1
公开(公告)日：2012-08-29
申请号：EP10774072.2
申请日：2010-10-20
发明人： BEIGHT, Douglas, Wade , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , EGGEN, MariJean , HENRY, Kenneth, James, Junior , JOHNS, Deidre, Michelle , PARTHASARATHY, Saravanan , PEI, Huaxing , REMPALA, Mark, Edward , SAWYER, Jason, Scott
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
摘要： The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.
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公开(公告)号：EP1904494A1
公开(公告)日：2008-04-02
申请号：EP06735794.7
申请日：2006-02-23
发明人： BARDA, David, Anthony , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , HAO, Yan , HEATH, Perry, Clark , HENRY, James, Robert , KNOBELOCH, John, Monte , MENDEL, David , MCLEAN, Johnathan, Alexander , REMICK, David, Michael , REMPALA, Mark, Edward , WANG, Zhao-Qing , YIP, Yvonne, Yee, Mai , ZHONG, Boyu
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/04
CPC分类号： C07D471/04
摘要： The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.
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公开(公告)号：EP1567527A1
公开(公告)日：2005-08-31
申请号：EP03783318.3
申请日：2003-11-24
发明人： BEIGHT, Douglas, Wade , BURKHOLDER, Timothy, Paul , DECOLLO, Todd, Vincent , GODFREY, Alexander, Glenn , HEAP, Charles, Raymond , KING, Chi-Hsin, Richard , LI, Hong-Yu , MCMILLEN, William, Thomas , SAWYER, Jason, Scott , WANG, Yan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , MALHOTRA, Sushant , MUNDLA, Sreenivasa, Reedy
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00 , C07D519/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula:(Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
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公开(公告)号：EP1483265A1
公开(公告)日：2004-12-08
申请号：EP03711146.5
申请日：2003-03-04
发明人： CLAYTON, Joshua, Ryan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , MALHOTRA, Sushant , MARQUART, Angela, Lynn , MCLEAN, Johnathan, Alexander , MENDEL, David , BURKHOLDER, Timothy, Paul , LI, Yihong , REEL, Jon, Kevin , SULLIVAN, John Morris , BERRIDGE, Brian Raymond , RUEGG, Charles Edward
IPC分类号： C07D487/06 , A61P25/08
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
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公开(公告)号：EP2491032B1
公开(公告)日：2014-04-16
申请号：EP10774072.2
申请日：2010-10-20
发明人： BEIGHT, Douglas, Wade , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , EGGEN, MariJean , HENRY, Kenneth, James, Junior , JOHNS, Deidre, Michelle , PARTHASARATHY, Saravanan , PEI, Huaxing , REMPALA, Mark, Edward , SAWYER, Jason, Scott
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07D487/04
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公开(公告)号：EP1487822A2
公开(公告)日：2004-12-22
申请号：EP03713551.4
申请日：2003-03-05
发明人： ALBAUGH, Pamela, Ann , AMMENN, Jochen , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , CONNER, Scott, Eugene , CUNNINGHAM, Brian, Eugene , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , LI, YiHong , MALHOTRA, Sushant , TEBBE, Mark, Joseph , ZHU, Guoxin , BERRIDGE, Brian Raymond , RUEGG, Charles Edward , SULLIVAN, John Morris
IPC分类号： C07D401/14 , A61K31/404 , A61P43/00 , C07D471/04 , C07D405/14 , C07D491/04 , C07D451/04
CPC分类号： C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The present invention provides kinase inhibitors of Formula (I)
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公开(公告)号：EP1204660A1
公开(公告)日：2002-05-15
申请号：EP00950264.2
申请日：2000-07-21
发明人： BRINER, Karin , BURKHOLDER, Timothy, Paul , CONWAY, Richard, Gerard , CUNNINGHAM, Brian, Eugene , FINLEY, Don, Richard , HEINZ, Lawrence, Joseph , JESUDASON, Cynthia, Darshini , KOHLMAN, Daniel, Timothy , LIANG, Sidney, Xi , XU, Yao-Chang
IPC分类号： C07D409/04 , A61K31/4535 , A61P25/24 , A61P3/04
CPC分类号： C07D409/04
摘要： The present invention provides serotonergic benzothiophenes of Formula (I), where A, R, R?1, R2, R3, and R4¿ are as described in the specification.
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公开(公告)号：EP1204659A2
公开(公告)日：2002-05-15
申请号：EP00955245.6
申请日：2000-07-21
发明人： BRINER, Karin , BURKHART, Joseph, Paul , BURKHOLDER, Timothy, Paul , CUNNINGHAM, Brian, Eugene , FISHER, Matthew, Joseph , GRITTON, William, Harlan , JESUDASON, Cynthia, Darshini , MILLER, Shawn, Christopher , MULLANEY, Jeffrey, Thomas , REINHARD, Matthew, Robert , ROTHHAAR, Roger, Ryan , STEVENS, Freddie, Craig , WINNEROSKI, Leonard, Larry, Jr. , XU, Yanping , XU, Yao-Chang
IPC分类号： C07D405/04 , A61K31/4525 , A61P3/04 , A61P25/24
CPC分类号： C07D405/04
摘要： The present invention provides serotonergic benzofurans of Formula (I): where A, R, R?1, R2, R3, and R4¿ are as described in the specification.
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公开(公告)号：EP1904494B1
公开(公告)日：2010-12-01
申请号：EP06735794.7
申请日：2006-02-23
发明人： BARDA, David, Anthony , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , HAO, Yan , HEATH, Perry, Clark , HENRY, James, Robert , KNOBELOCH, John, Monte , MENDEL, David , MCLEAN, Johnathan, Alexander , REMICK, David, Michael , REMPALA, Mark, Edward , WANG, Zhao-Qing , YIP, Yvonne, Yee, Mai , ZHONG, Boyu
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/04
CPC分类号： C07D471/04
摘要： The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.
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