公开(公告)号：EP2209806A1

公开(公告)日：2010-07-28

申请号：EP08844586.1

申请日：2008-10-29

申请人： ELI LILLY AND COMPANY

发明人： CAI, Yuping, Anthony ,  GATELY, Dennis, Patrick ,  HE, Luhong ,  LEUNG, Donmienne, Doen ,  LUAN, Peng ,  SWANSON, Barbara, Anne ,  TANG, Ying ,  WITCHER, Derrick, Ryan

IPC分类号： C07K16/18

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.

公开(公告)号：EP2209806B1

公开(公告)日：2012-08-22

申请号：EP08844586.1

申请日：2008-10-29

申请人： ELI LILLY AND COMPANY

发明人： CAI, Yuping, Anthony ,  GATELY, Dennis, Patrick ,  HE, Luhong ,  LEUNG, Donmienne, Doen ,  LUAN, Peng ,  SWANSON, Barbara Anne ,  TANG, Ying ,  WITCHER, Derrick, Ryan

IPC分类号： C07K16/18

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.