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公开(公告)号：EP1670827A2
公开(公告)日：2006-06-21
申请号：EP04780441.4
申请日：2004-09-02
IPC分类号： C07K16/28 , C12N15/68 , C12N5/10 , A61K39/395 , C12N15/13
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which bind acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full- length antibody or an antigen-binding portion thereof. The antibodies of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
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公开(公告)号：EP2328931A1
公开(公告)日：2011-06-08
申请号：EP09790908.9
申请日：2009-07-29
发明人： LEUNG, Donmienne, Doen, Mun , LUAN, Peng , TANG, Ying , WITCHER, Derrick, Ryan , YACHI, Pia, Pauliina
IPC分类号： C07K16/26 , G01N33/577 , A61K39/395 , A61P7/06
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/92 , G01N33/74
摘要： Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
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公开(公告)号：EP1135493A2
公开(公告)日：2001-09-26
申请号：EP99967124.1
申请日：1999-11-23
发明人： BEALS, John, Michael , GLAESNER, Wolfgang , MICANOVIC, Radmilla , MILLICAN, Rohn, Lee, Jr. , WITCHER, Derrick, Ryan
IPC分类号： C12N15/12 , C12N1/21 , C07K14/505 , A61K47/48 , A61K38/18 , A01K67/027 , A61P7/06
CPC分类号： C07K14/505 , A01K2217/05 , A61K38/1816 , A61K47/60
摘要： The present invention addresses the need for better pharmaceutical agents for treating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.
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公开(公告)号：EP2209806A1
公开(公告)日：2010-07-28
申请号：EP08844586.1
申请日：2008-10-29
发明人： CAI, Yuping, Anthony , GATELY, Dennis, Patrick , HE, Luhong , LEUNG, Donmienne, Doen , LUAN, Peng , SWANSON, Barbara, Anne , TANG, Ying , WITCHER, Derrick, Ryan
IPC分类号： C07K16/18
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
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公开(公告)号：EP1633397A2
公开(公告)日：2006-03-15
申请号：EP04775963.4
申请日：2004-05-28
IPC分类号： A61K39/395
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which preferentially bind acetylated human ghrelin with respect to unacylated human ghrelin are disclosed. These antibodies have high affinity for acylated human ghrelin, a slow off rate for acylated human ghrelin dissociation and neutralize an acylated human ghrelin activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antigen-binding portions, of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
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公开(公告)号：EP1432735A2
公开(公告)日：2004-06-30
申请号：EP02756428.5
申请日：2002-08-15
发明人： GELFANOVA, Valentina, Pavlovna , HALE, John, Edward , KIKLY, Kristine, Kay , WITCHER, Derrick, Ryan , RATHNACHALAM, Radhakrishnan
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2875 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/53 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD = 10-8 M or less), a slow off rate for TNFSF13b dissociation (e.g., K¿off? = 10?-3 sec-1¿ or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
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公开(公告)号：EP1355945A2
公开(公告)日：2003-10-29
申请号：EP02714718.0
申请日：2002-01-18
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K14/70578 , A61K38/00
摘要： The present invention provides FLINT isoforms having an average sialic acid content of 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0 or greater than 4.0 per molecule of FLINT. Also provided are mixtures of said isoforms, and methods for making said isoforms.
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公开(公告)号：EP2328931B1
公开(公告)日：2013-08-14
申请号：EP09790908.9
申请日：2009-07-29
发明人： LEUNG, Donmienne, Doen, Mun , LUAN, Peng , TANG, Ying , WITCHER, Derrick, Ryan , YACHI, Pia, Pauliina
IPC分类号： C07K16/26 , G01N33/577 , A61K39/395 , A61P7/06
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/92 , G01N33/74
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公开(公告)号：EP2209806B1
公开(公告)日：2012-08-22
申请号：EP08844586.1
申请日：2008-10-29
发明人： CAI, Yuping, Anthony , GATELY, Dennis, Patrick , HE, Luhong , LEUNG, Donmienne, Doen , LUAN, Peng , SWANSON, Barbara Anne , TANG, Ying , WITCHER, Derrick, Ryan
IPC分类号： C07K16/18
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
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公开(公告)号：EP2373335A1
公开(公告)日：2011-10-12
申请号：EP09760073.8
申请日：2009-12-01
发明人： LEUNG, Donmienne, Doen, Mun , LUAN, Peng , MANETTA, Joseph, Vincent , TANG, Ying , WITCHER, Derrick, Ryan
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject
in vivo .
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