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1.发明公开Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors 有权取代Karbazole，它们的制备方法和它们作为抑制剂的用途sPLA2-
公开(公告)号：EP0952149A3
公开(公告)日：2001-08-16
申请号：EP99302941.2
申请日：1999-04-16
发明人： Anderson, Benjamin Alan , Bach, Nicholas James , Bastian, Jolie Anne , Harn, Nancy Kay , Harper, Richard Waltz , Hite, Gary Alan , Kinnick, Michael Dean , Lin, Ho-Shen , Loncharich, Richard James , McGill, John McNeill , Mihelich, Edward David , Morin jr., John Michael , Phillips, Michael LeRoy , Richett, Michael Enrico , Sall, Daniel Jon , Sawyer,Jason Scott , Schevitz, Richard Walter , Vasileff, Robert Theodore
IPC分类号： C07D209/88 , C07D209/86 , C07C205/59 , C07C229/48 , C07C229/60 , A61K31/40
CPC分类号： C07D209/88 , Y02P20/55
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
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公开(公告)号：EP0997465B1
公开(公告)日：2004-02-04
申请号：EP99308494.6
申请日：1999-10-27
发明人： Bastian, Jolie Anne , Fisher, Matthew Joseph , Harper, Richard Waltz , Lin, Ho-Shen , McCowan, Jefferson Ray , Sall, Daniel Jon , Smith, Gerald Floyd , Takeuchi, Kumiko , Wiley, Michael Robert , Zhang, Minsheng
IPC分类号： C07D487/04 , A61K31/435
CPC分类号： C07D471/04
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3.发明公开Azaindole derivatives and their use as antithrombotic agents 有权Azaindol衍生物和Verhendung als antithrombotische Wirkstoffe
公开(公告)号：EP0997465A1
公开(公告)日：2000-05-03
申请号：EP99308494.6
申请日：1999-10-27
发明人： Bastian, Jolie Anne , Fisher, Matthew Joseph , Harper, Richard Waltz , Lin, Ho-Shen , McCowan, Jefferson Ray , Sall, Daniel Jon , Smith, Gerald Floyd , Takeuchi, Kumiko , Wiley, Michael Robert , Zhang, Minsheng
IPC分类号： C07D487/04 , A61K31/435
CPC分类号： C07D471/04
摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
摘要翻译： 本申请涉及本文所定义的式I（及其药学上可接受的盐）的新化合物，其制备方法和中间体，包含式I的新型化合物的药物制剂，以及式I化合物作为凝血酶抑制剂的用途 。
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4.发明授权Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors 有权取代Karbazole，它们的制备方法和它们作为抑制剂的用途sPLA2-
公开(公告)号：EP0952149B1
公开(公告)日：2004-06-09
申请号：EP99302941.2
申请日：1999-04-16
发明人： Anderson, Benjamin Alan , Bach, Nicholas James , Bastian, Jolie Anne , Harn, Nancy Kay , Harper, Richard Waltz , Hite, Gary Alan , Kinnick, Michael Dean , Lin, Ho-Shen , Loncharich, Richard James , McGill, John McNeill , Mihelich, Edward David , Morin jr., John Michael , Phillips, Michael LeRoy , Richett, Michael Enrico , Sall, Daniel Jon , Sawyer,Jason Scott , Schevitz, Richard Walter , Vasileff, Robert Theodore
IPC分类号： C07D209/88 , C07D209/86 , C07C205/59 , C07C229/48 , C07C229/60 , A61K31/40
CPC分类号： C07D209/88 , Y02P20/55
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公开(公告)号：EP0562849A3
公开(公告)日：1994-02-16
申请号：EP93302261.8
申请日：1993-03-24
发明人： Archer, Robert Allen , Beavers, Lisa Selsam , Gadski, Robert Alan , Lin, Ho-Shen , McClure, Don B. , McCowan, Jefferson Ray , Pawlak, Joseph Matthew , Rampersaud, Ashraff Ali , Schmidt, Robert John , Schreyer, Teri Ann , Yu, Melvin Joseph
IPC分类号： C07J9/00 , A61K31/56 , C07J41/00 , C07J21/00 , C07J1/00 , C07J51/00 , C07J17/00 , C07J3/00 , C07J43/00
CPC分类号： C07J51/00 , A61K31/56 , A61K31/57 , A61K31/575 , A61K31/58 , C07J1/0029 , C07J3/00 , C07J3/005 , C07J9/00 , C07J17/00 , C07J21/006 , C07J41/0005 , C07J41/0011 , C07J41/0055 , C07J41/0094 , C07J43/003 , A61K2300/00
摘要： This invention relates to steroid derivatives, pharmaceutical formulations containing those compounds alone or together with other cholesterol control agents, and methods of their use for upregulating LDL receptor gene expression, lowering serum LDL cholesterol and/or inhibiting atherosclerosis. Said steroid derivatives have the formula :
摘要翻译： 本发明涉及类固醇衍生物，含有单独或与其它胆固醇控制剂一起的那些化合物的药物制剂，以及它们用于上调LDL受体基因表达，降低血清LDL胆固醇和/或抑制动脉粥样硬化的方法。 所述类固醇衍生物具有下式：
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6.发明公开Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors 有权取代Karbazole，它们的制备方法和它们作为抑制剂的用途sPLA2-
公开(公告)号：EP0952149A2
公开(公告)日：1999-10-27
申请号：EP99302941.2
申请日：1999-04-16
发明人： Anderson, Benjamin Alan , Bach, Nicholas James , Bastian, Jolie Anne , Harn, Nancy Kay , Harper, Richard Waltz , Hite, Gary Alan , Kinnick, Michael Dean , Lin, Ho-Shen , Loncharich, Richard James , McGill, John McNeill , Mihelich, Edward David , Morin jr., John Michael , Phillips, Michael LeRoy , Richett, Michael Enrico , Sall, Daniel Jon , Sawyer,Jason Scott , Schevitz, Richard Walter , Vasileff, Robert Theodore
IPC分类号： C07D209/88 , C07D209/86 , C07C205/59 , C07C229/48 , C07C229/60 , A61K31/40
CPC分类号： C07D209/88 , Y02P20/55
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
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公开(公告)号：EP0562849A2
公开(公告)日：1993-09-29
申请号：EP93302261.8
申请日：1993-03-24
发明人： Archer, Robert Allen , Beavers, Lisa Selsam , Gadski, Robert Alan , Lin, Ho-Shen , McClure, Don B. , McCowan, Jefferson Ray , Pawlak, Joseph Matthew , Rampersaud, Ashraff Ali , Schmidt, Robert John , Schreyer, Teri Ann , Yu, Melvin Joseph
IPC分类号： C07J9/00 , A61K31/56 , C07J41/00 , C07J21/00 , C07J1/00 , C07J51/00 , C07J17/00 , C07J3/00 , C07J43/00
CPC分类号： C07J51/00 , A61K31/56 , A61K31/57 , A61K31/575 , A61K31/58 , C07J1/0029 , C07J3/00 , C07J3/005 , C07J9/00 , C07J17/00 , C07J21/006 , C07J41/0005 , C07J41/0011 , C07J41/0055 , C07J41/0094 , C07J43/003 , A61K2300/00
摘要： This invention relates to steroid derivatives, pharmaceutical formulations containing those compounds alone or together with other cholesterol control agents, and methods of their use for upregulating LDL receptor gene expression, lowering serum LDL cholesterol and/or inhibiting atherosclerosis. Said steroid derivatives have the formula :
摘要翻译： 本发明涉及类固醇衍生物，单独或与其它胆固醇控制剂一起含有那些化合物的药物制剂，及其用于上调LDL受体基因表达，降低血清LDL胆固醇和/或抑制动脉粥样硬化的方法。 所述类固醇衍生物具有下式：
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