公开(公告)号：EP1687292A2

公开(公告)日：2006-08-09

申请号：EP04819516.8

申请日：2004-11-16

申请人： ELI LILLY AND COMPANY

发明人： LU, Jianliang ,  MA, Tainwei ,  NAGPAL, Sunil ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  YEE, Ying, Kwong ,  RUPP, Michael, John

IPC分类号： C07D333/70 ,  C07D333/68 ,  A61K31/559 ,  A61P3/14

CPC分类号： C07D333/68 ,  C07D333/70

摘要： The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

公开(公告)号：EP1687292B1

公开(公告)日：2007-08-22

申请号：EP04819516.8

申请日：2004-11-16

申请人： ELI LILLY AND COMPANY

发明人： LU, Jianliang ,  MA, Tainwei ,  NAGPAL, Sunil ,  SHEN, Quanrong ,  WARSHAWSKY, Alan, M. ,  YEE, Ying, Kwong ,  RUPP, Michael, John

IPC分类号： C07D333/70 ,  C07D333/68 ,  A61K31/559 ,  A61P3/14

CPC分类号： C07D333/68 ,  C07D333/70

摘要： The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

摘要翻译： 本发明涉及具有维生素D受体（VDR）调节活性的新型非 - 类固醇，苯基 - 苯并噻吩化合物，其比1α，25二羟基维生素D 3更低的高钙血症。 这些化合物可用于治疗骨疾病和牛皮癣。