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公开(公告)号：EP1817287B1
公开(公告)日：2010-02-10
申请号：EP05851607.1
申请日：2005-11-10
发明人： ARGADE, Ankush, B., Rigel Pharmaceuticals, Inc. , GOODSON, Theodore, Junior , HERRON, David, Kent , JOSEPH, Sajan , LEPORE, Salvatore, Donato , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D211/46 , C07D213/75 , C07D401/12 , C07D401/14 , C07D417/12 , C07D295/18 , C07D409/14 , C07D413/12 , C07D333/38 , C07D409/06 , A61K31/4427 , A61P7/00 , A61K31/381 , A61K31/44 , C07C271/16
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
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公开(公告)号：EP1836151B1
公开(公告)日：2009-04-01
申请号：EP05854992.4
申请日：2005-12-19
IPC分类号： C07C65/40 , C07C65/24 , A61K31/165 , A61K31/19 , A61P3/14
CPC分类号： C07C235/42 , C07C65/24 , C07C65/40 , C07C217/80 , C07C271/30
摘要： The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, Z P , L P1 , L P2 L NP , RP 3 , RN, and Z NP are defined herein, their preparation, pharmaceutical compositions, and methods of use.
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公开(公告)号：EP1687292A2
公开(公告)日：2006-08-09
申请号：EP04819516.8
申请日：2004-11-16
发明人： LU, Jianliang , MA, Tainwei , NAGPAL, Sunil , SHEN, Quanrong , WARSHAWSKY, Alan, M. , YEE, Ying, Kwong , RUPP, Michael, John
IPC分类号： C07D333/70 , C07D333/68 , A61K31/559 , A61P3/14
CPC分类号： C07D333/68 , C07D333/70
摘要： The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号：EP1687289A1
公开(公告)日：2006-08-09
申请号：EP04800486.5
申请日：2004-11-16
发明人： LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , SHEN, Quanrong , WARSHAWSKY, Alan, M. , OCHOADA, Jason, Matthew , YEE, Ying, Kwong
IPC分类号： C07D307/77 , C07D405/12 , C07D407/10 , C07D407/12 , A61K31/12
CPC分类号： C07D405/12 , C07D307/80 , C07D407/12
摘要： The present invention relates to novel, non-secosteroidal, phenyl-benzofuran compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译： 本发明涉及具有维生素D受体（VDR）调节活性的新型非 - 类固醇，苯基 - 苯并呋喃化合物，其比1α，25二羟基维生素D 3更低的高钙血症。 这些化合物可用于治疗骨疾病和牛皮癣。
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公开(公告)号：EP1140903B1
公开(公告)日：2004-08-04
申请号：EP99964279.6
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , DENNY, Carl, Penman , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan Pariyadan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D405/14 , C07D213/74 , A61K31/395 , A61K31/435 , A61K31/495 , A61P7/02
CPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
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公开(公告)号：EP1311501A1
公开(公告)日：2003-05-21
申请号：EP01961622.6
申请日：2001-08-06
发明人： BEIGHT, Douglas, Wade , MASTERS, JOHN, Joseph , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D403/14 , A61K31/4015 , A61P7/02 , A61P9/10
CPC分类号： C07D401/14 , C07D403/12
摘要： This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositionsthereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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7.发明授权
公开(公告)号：EP1692123B1
公开(公告)日：2008-05-28
申请号：EP04810027.5
申请日：2004-11-16
发明人： GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
IPC分类号： C07D307/68 , A61K31/341 , A61P35/00
CPC分类号： C07D307/68
摘要： The present invention relates to novel, non-secosteroidal, phenyl-furan compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号：EP1307444B1
公开(公告)日：2007-10-03
申请号：EP01958825.0
申请日：2001-07-18
发明人： HERRON, David, Kent , JOSEPH, Sajan , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , SMITH, Gerald, Floyd , WAID, Philip, Parker , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D401/14 , C07D401/12 , C07D213/81 , C07D237/24 , A61K31/4402 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61P7/02
CPC分类号： C07D401/14 , C07D237/24 , C07D403/04
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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公开(公告)号：EP1817287A1
公开(公告)日：2007-08-15
申请号：EP05851607.1
申请日：2005-11-10
发明人： ARGADE, Ankush, B., Rigel Pharmaceuticals, Inc. , GOODSON, Theodore, Junior , HERRON, David, Kent , JOSEPH, Sajan , LEPORE, Salvatore, Donato , MARQUART, Angela, Lynn , MASTERS, John, Joseph , MENDEL, David , MERRITT, Leander , RATZ, Andrew, Michael , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , WILEY, Michael, Robert , YEE, Ying, Kwong
IPC分类号： C07D211/46 , C07D213/75 , C07D401/12 , C07D401/14 , C07D417/12 , C07D295/18 , C07D409/14 , C07D413/12 , C07D333/38 , C07D409/06 , A61K31/4427 , A61P7/00 , A61K31/381 , A61K31/44 , C07C271/16
CPC分类号： C07D211/46 , C07C229/38 , C07D213/75 , C07D295/192 , C07D333/38 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).
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公开(公告)号：EP1140881B1
公开(公告)日：2006-05-17
申请号：EP99964269.7
申请日：1999-12-15
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , JOSEPH, Sajan , KLIMKOWSKI, Valentine, Joseph , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , PINEIRO-NUNEZ, Marta, Maria , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , YEE, Ying, Kwong , Kyle, Jefferey.A
IPC分类号： C07D295/12 , C07D401/04 , C07D401/12 , C07D409/14 , C07D401/14 , A61K31/44 , A61K31/445
CPC分类号： C07D295/135 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/14
摘要： This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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