公开(公告)号：EP1567188B1

公开(公告)日：2012-07-11

申请号：EP04785951.7

申请日：2004-06-21

申请人： ELI LILLY AND COMPANY

发明人： CHAM, Bill, E. ,  MALTAIS, Jo-Ann, B. ,  BELLOTTI, Marc

IPC分类号： A61K39/00 ,  A61K39/12 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  A61K39/29 ,  A61K47/6901 ,  A61K2039/5252 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16134 ,  C12N2770/20034

摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides for the use of these modified viral particles in the preparation of medicaments for prevention and/or treatment of one or more viral diseases in a patient. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine composition of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.