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公开(公告)号：EP0722941A3
公开(公告)日：2000-04-12
申请号：EP96300286.0
申请日：1996-01-15
发明人： Audia, James E. , Hibschman, David J. , Krushinski Jr., Joseph H. , Mabry, Thomas E. , Nissen, Jeffrey S. , Rasmussen, Kurt , Rocco, Vincent P. , Schaus, John M. , Thompson, Dennis C. , Wong, David T.
IPC分类号： C07D401/12 , C07D403/12 , C07D401/14 , C07D403/14 , C07D471/10 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/445 , A61K31/495
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1 A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
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2.发明公开Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) for treating substance abuse 失效使用3-（4-己氧基-1,2,5-噻二唑-3-基）-1,2,5,6-四氢-1-甲基吡啶（呫诺美林）对于药物滥用的治疗
公开(公告)号：EP0821957A3
公开(公告)日：1998-04-22
申请号：EP97305592.4
申请日：1997-07-25
发明人： Rasmussen, Kurt
IPC分类号： A61K31/44
CPC分类号： A61K31/4439
摘要： The present invention provides a method for treating substance abuse in humans using a compound of the Formula I
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公开(公告)号：EP0768087A2
公开(公告)日：1997-04-16
申请号：EP96305948.0
申请日：1996-08-14
发明人： Watanabe, August Masaru , Bumol, Thomas Frank , Steinberg, Mitchell Irvin , Kallman, Mary Jeanne , Rasmussen, Kurt
IPC分类号： A61K31/505 , A61K31/00
CPC分类号： A61K31/506 , A61K31/00 , A61K31/505 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S977/773 , Y10S977/775 , Y10S977/801 , Y10S977/904 , Y10S977/907
摘要： This invention provides a method for treating a condition resulting from the cessation or withdrawal of tobacco or nicotine, opioids, ethanol or combinations thereof comprising administering an effective amount of 4-chloro-5-(imidazoline-2-yl(amino)-6-methoxy-2-methylpyrimidine.
摘要翻译： 本发明提供了一种治疗由烟草或尼古丁，阿片样物质，乙醇或其组合的停止或停药引起的病症的方法，其包括给予有效量的4-氯-5-（咪唑啉-2-基（氨基）-6- 甲氧基-2-甲基嘧啶。
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公开(公告)号：EP0768087A3
公开(公告)日：2000-01-26
申请号：EP96305948.0
申请日：1996-08-14
发明人： Watanabe, August Masaru , Bumol, Thomas Frank , Steinberg, Mitchell Irvin , Kallman, Mary Jeanne , Rasmussen, Kurt
IPC分类号： A61K31/505 , A61K31/00
CPC分类号： A61K31/506 , A61K31/00 , A61K31/505 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S977/773 , Y10S977/775 , Y10S977/801 , Y10S977/904 , Y10S977/907
摘要： This invention provides a method for treating a condition resulting from the cessation or withdrawal of tobacco or nicotine, opioids, ethanol or combinations thereof comprising administering an effective amount of 4-chloro-5-(imidazoline-2-yl(amino)-6-methoxy-2-methylpyrimidine.
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5.发明公开Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) for treating substance abuse 失效Verwendung von 3-（4-己氧基-1,2,5-噻二唑-3-基）-1,2,5,6-四氢-1-甲基吡啶（Xanomelin）zur Behandlung von Drogenmissbrauch
公开(公告)号：EP0821957A2
公开(公告)日：1998-02-04
申请号：EP97305592.4
申请日：1997-07-25
发明人： Rasmussen, Kurt
IPC分类号： A61K31/44
CPC分类号： A61K31/4439
摘要： The present invention provides a method for treating substance abuse in humans using a compound of the Formula I
摘要翻译： 本发明提供使用式I
的化合物治疗人体物质滥用的方法 -
公开(公告)号：EP0722941A2
公开(公告)日：1996-07-24
申请号：EP96300286.0
申请日：1996-01-15
发明人： Audia, James E. , Hibschman, David J. , Krushinski Jr., Joseph H. , Mabry, Thomas E. , Nissen, Jeffrey S. , Rasmussen, Kurt , Rocco, Vincent P. , Schaus, John M. , Thompson, Dennis C. , Wong, David T.
IPC分类号： C07D401/12 , C07D403/12 , C07D401/14 , C07D403/14 , C07D471/10 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/445 , A61K31/495
CPC分类号： C07D209/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/08 , C07D471/10 , C07D491/10 , C07D495/10 , C07D513/04
摘要： A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1 A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.
摘要翻译： 一系列异烷基链烷胺是用于治疗与5-羟色胺和5-羟色胺1A受体再摄取相关或受其影响的病症的有效药物。 该化合物特别可用于缓解尼古丁和烟草戒断的症状，以及治疗抑郁症和使用5-羟色胺再摄取抑制剂的其它病症。
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公开(公告)号：EP0642787A2
公开(公告)日：1995-03-15
申请号：EP94306537.5
申请日：1994-09-06
IPC分类号： A61K31/00 , A61K31/135 , A61K31/40 , A61K31/445 , A61K31/495
CPC分类号： A61K31/00 , A61K31/135 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/435 , A61K31/47 , A61K31/495
摘要： Pharmaceuticals which are 5HT 1A antagonists alleviate the symptoms of withdrawal from tobacco or nicotine and assist patients to withdraw from such use.
摘要翻译： 作为5HT1A拮抗剂的药物缓解了戒烟或尼古丁的症状并帮助患者退出此类用途。
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8.发明公开Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine for treating nicotine withdrawal 失效使用3-（4-己氧基-1,2,5-噻二唑-3-基）-1,2,5,6-四氢-1-甲基吡啶对尼古丁戒断治疗
公开(公告)号：EP0821959A3
公开(公告)日：1998-09-16
申请号：EP97305594.0
申请日：1997-07-25
发明人： Rasmussen, Kurt
IPC分类号： A61K31/44
CPC分类号： A61K31/4439
摘要： The present invention provides a method for treating a nicotine withdrawal in a mammal using a compound of the Formula I
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9.发明公开Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine for treating nicotine withdrawal 失效Verwendung von 3-（4-己氧基-1,2,5-噻二唑-3-基）-1,2,5,6-四氢-1-甲基吡啶zur Behandlung von Nikotin-Entzug
公开(公告)号：EP0821959A2
公开(公告)日：1998-02-04
申请号：EP97305594.0
申请日：1997-07-25
发明人： Rasmussen, Kurt
IPC分类号： A61K31/44
CPC分类号： A61K31/4439
摘要： The present invention provides a method for treating a nicotine withdrawal in a mammal using a compound of the Formula I
摘要翻译： 本发明提供使用式I化合物
治疗哺乳动物中尼古丁戒断的方法 -
公开(公告)号：EP0738515A1
公开(公告)日：1996-10-23
申请号：EP96302712.3
申请日：1996-04-18
发明人： Rasmussen, Kurt
IPC分类号： A61K31/55
CPC分类号： A61K31/551 , Y10S514/813
摘要： Use of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b] [1,5] benzodiazepine, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for treating a condition resulting from the cessation and withdrawal from the use of nicotine.
摘要翻译： 2-甲基-4-（4-甲基-1-哌嗪基）-10H-噻吩并[2,3-b]哒嗪2,3-二苯并吖庚因或其药学上可接受的盐在制备用于治疗由 停止使用尼古丁戒烟。
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