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公开(公告)号：EP1131321B1
公开(公告)日：2003-09-10
申请号：EP99972634.2
申请日：1999-11-18
IPC分类号： C07D417/14 , C07D401/14 , A61K31/549 , A61K31/5415 , A61K31/475 , A61K31/454 , C07D285/16 , C07D285/10 , C07D215/22 , C07D215/36 , C07D209/34
CPC分类号： C07D215/227 , C07D209/34 , C07D215/36 , C07D285/10 , C07D285/16 , C07D401/14 , C07D417/14
摘要： A pharmaceutical compound of formula (I) in which R?1 and R2¿ are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, X is (1) or (2), Y is (3) or (4) where R?4 and R5¿ are each hydrogen, C¿1-6? alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl, n is 0 or 1, and R?3 is -SR6, -SOR6, -SO¿2R?6, -COR6, -CH¿2OH or -CONHR7, where R6 is C¿1-6? alkyl and R?7¿ is hydrogen or C¿1-6? alkyl; provided that when one of R?1 and R2¿ is hydrogen and the other is fluoro, X is (1), Y is (4), R?4 and R5¿ are each hydrogen or C¿1-6? alkyl, and n is 0, then R?3¿ is not -COR6 or -CONHR7; and salts thereof.
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公开(公告)号：EP1131321A2
公开(公告)日：2001-09-12
申请号：EP99972634.2
申请日：1999-11-18
IPC分类号： C07D417/14 , C07D401/14 , A61K31/549 , A61K31/5415 , A61K31/475 , A61K31/454 , C07D285/16 , C07D285/10 , C07D215/22 , C07D215/36 , C07D209/34
CPC分类号： C07D215/227 , C07D209/34 , C07D215/36 , C07D285/10 , C07D285/16 , C07D401/14 , C07D417/14
摘要： A pharmaceutical compound of formula (I) in which R?1 and R2¿ are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, X is (1) or (2), Y is (3) or (4) where R?4 and R5¿ are each hydrogen, C¿1-6? alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl, n is 0 or 1, and R?3 is -SR6, -SOR6, -SO¿2R?6, -COR6, -CH¿2OH or -CONHR7, where R6 is C¿1-6? alkyl and R?7¿ is hydrogen or C¿1-6? alkyl; provided that when one of R?1 and R2¿ is hydrogen and the other is fluoro, X is (1), Y is (4), R?4 and R5¿ are each hydrogen or C¿1-6? alkyl, and n is 0, then R?3¿ is not -COR6 or -CONHR7; and salts thereof.
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