公开(公告)号：EP2121648A2

公开(公告)日：2009-11-25

申请号：EP07753654.8

申请日：2007-03-21

申请人： EPIX Pharmaceuticals, Inc.

发明人： SAHA, Ashis ,  YU, Xiang, Y. ,  LOBERA, Mercedes ,  LIN, Jian ,  CHERUKU, Srinivasa, R. ,  BECKER, Oren ,  MARANTZ, Yael ,  SCHUTZ, Nili ,  BURLI, Roland ,  CEE, Victor, J. ,  GOLDEN, Jennifer ,  LANMAN, Brian, Alan ,  NEIRA, Susana ,  ORBACH, Pini ,  McCAULEY, Dilara. ,  SHARADENDU, Anurag. ,  SHACHAM, Sharon. ,  PENLAND, Robert.C. ,  NOIMAN, Silvia. ,  GANNON, Kimberley. ,  ZHANG, Zhaoda.

IPC分类号： C07D307/81 ,  C07D405/10 ,  C07D405/04 ,  C07D405/14 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10 ,  C07D471/04 ,  C07D491/04

CPC分类号： C07D491/048 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.