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    Diagnostic imaging contrast agents with extended blood retention
    1.
    发明公开
    Diagnostic imaging contrast agents with extended blood retention 失效
    造影剂与血液中的延长停留时间，诊断成像

    公开(公告)号：EP1716871A3

    公开(公告)日：2011-04-27

    申请号：EP06016539.6

    申请日：1996-01-16

    申请人： EPIX Pharmaceuticals, Inc.

    发明人： McMurry, Thomas, J. ,  Sajiki, Hironao ,  Scott, Daniel, M. ,  Lauffer, Randall, B.

    IPC分类号： A61K49/00 ,  A61K51/04

    CPC分类号： A61K49/085 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07F9/091

    摘要： The present invention provides diagnostic imaging contrast agents which exhibit improved blood retention. The novel compounds comprise: a) an image-enhancing (or signal-generating) moiety (IEM); b) a plasma protein binding moiety (PPBM); and c) a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging. These contrast agents exhibit reduced rates of both renal and hepatocellular uptake and no apparent uptake by the RE system. The agents may be targeted to the blood pool or any other biological component. Since the agent is lost less rapidly from the bloodstream, lower doses can be used at a higher margin of safety. The approach is general to both large and small molecules.

    STEADY STATE PERFUSION METHODS
    8.
    发明公开
    STEADY STATE PERFUSION METHODS 审中-公开
    稳态，PERFUSIONSVERFAHREN

    公开(公告)号：EP1848465A2

    公开(公告)日：2007-10-31

    申请号：EP06720404.0

    申请日：2006-02-03

    申请人： EPIX Pharmaceuticals, Inc.

    发明人： WEISSKOFF, Robert, M.

    IPC分类号： A61K49/00

    CPC分类号： A61K49/103

    摘要： Methods for assessing ischemic coronary artery disease are provided. The methods include administering a contrast agent that binds to a serum protein component to an animal and obtaining an MR image of the animal's myocardium during a period when the animal is experiencing hyperemia.

    Diagnostic imaging contrast agents with extended blood retention
    9.
    发明公开
    Diagnostic imaging contrast agents with extended blood retention 失效
    造影剂与血液中的延长停留时间，诊断成像

    公开(公告)号：EP1716871A2

    公开(公告)日：2006-11-02

    申请号：EP06016539.6

    申请日：1996-01-16

    申请人： EPIX Pharmaceuticals, Inc.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： A61K49/18 ,  C07F9/09

    CPC分类号： A61K49/085 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07F9/091

    摘要： The present invention provides diagnostic imaging contrast agents which exhibit improved blood retention. The novel compounds comprise: a) an image-enhancing (or signal-generating) moiety (IEM); b) a plasma protein binding moiety (PPBM); and c) a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging. These contrast agents exhibit reduced rates of both renal and hepatocellular uptake and no apparent uptake by the RE system. The agents may be targeted to the blood pool or any other biological component. Since the agent is lost less rapidly from the bloodstream, lower doses can be used at a higher margin of safety. The approach is general to both large and small molecules.

    摘要翻译： 本发明提供了表现出改进的血中滞留性的诊断成像造影剂。 的新化合物包括：a）一个图像增强（或信号产生）部分（IEM）; b）一种血浆蛋白结合部分（PPBM）; 和c）血液半衰期延长部分（BHEM）。 本发明因此涉及药物组合物，其包括合成的化合物和使用所述化合物和组合物用于血液半衰期延长和诊断成像的对比度增强的方法。 这些造影剂表现出降低的肾功能都和肝摄取和没有明显的摄取由RE系统的速率。所述药剂可以靶向血池或任何其他生物组分。 由于剂从血液中失去较慢，较低的剂量可以在较高的安全余量来使用。 该方法是由一般到大和小分子。

    DIAGNOSTIC IMAGING CONTRAST AGENTS WITH EXTENDED BLOOD RETENTION
    10.
    发明授权
    DIAGNOSTIC IMAGING CONTRAST AGENTS WITH EXTENDED BLOOD RETENTION 失效
    对于诊断成像造影剂延长停留在血液中

    公开(公告)号：EP0806968B1

    公开(公告)日：2006-10-18

    申请号：EP96902106.2

    申请日：1996-01-16

    申请人： EPIX Pharmaceuticals, Inc.

    发明人： McMURRY, Thomas, J. ,  SAJIKI, Hironao ,  SCOTT, Daniel, M. ,  LAUFFER, Randall, B.

    IPC分类号： A61K49/10

    CPC分类号： A61K49/085 ,  A61B6/507 ,  A61K49/0002 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  C07F9/091

    摘要： The present invention provides diagnostic imaging contrast agents which exhibit improved blood retention. The novel compounds comprise: a) an image-enhancing (or signal-generating) moiety (IEM); b) a plasma protein binding moiety (PPBM); and c) a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging. These contrast agents exhibit reduced rates of both renal and hepatocellular uptake and no apparent uptake by the RE system. The agents may be targeted to the blood pool or any other biological component. Since the agent is lost less rapidly from the bloodstream, lower doses can be used at a higher margin of safety. The approach is general to both large and small molecules.