公开(公告)号：EP2364976A1

公开(公告)日：2011-09-14

申请号：EP10016060.5

申请日：2007-03-21

申请人： EPIX Pharmaceuticals, Inc.

发明人： Saha, Ashis ,  Yu, Xiang Y. ,  Lobera, Mercedes ,  Lin, Jian ,  Cheruku, Srinivasa R. ,  Becker, Oren ,  Marantz, Yael ,  Schutz, Nili ,  Burli, Roland ,  Cee, Victor J. ,  Golden, Jennifer ,  Lanman, Brian Alan ,  Neira, Susana ,  Orbach, Pini ,  McCauley, Dilara ,  Sharadendu, Anurag ,  Shacham, Sharon ,  Penland, Robert C. ,  Noiman, Silvia ,  Gannon, Kimberley ,  Zhang, Zhaoda

IPC分类号： C07D277/66 ,  C07D491/048 ,  C07D263/57

CPC分类号： C07D491/048 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

摘要： The present invention relates to compounds of the general formula (I) that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SIP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

摘要翻译： 本发明涉及具有作为SIP受体调节剂的活性的通式（I）的化合物，以及这些化合物用于治疗与不适当的SIP受体活性有关的疾病的用途。 这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿病 关节炎，非肾小球性肾病，肝炎，贝切特氏病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳氏肉芽肿; 并处理其他条件。

公开(公告)号：EP2364976B1

公开(公告)日：2014-10-08

申请号：EP10016060.5

申请日：2007-03-21

申请人： EPIX Pharmaceuticals, Inc.

发明人： Saha, Ashis ,  Yu, Xiang Y. ,  Lobera, Mercedes ,  Lin, Jian ,  Cheruku, Srinivasa R. ,  Becker, Oren ,  Marantz, Yael ,  Schutz, Nili ,  Burli, Roland ,  Cee, Victor J. ,  Golden, Jennifer ,  Lanman, Brian Alan ,  Neira, Susana ,  Orbach, Pini ,  McCauley, Dilara ,  Sharadendu, Anurag ,  Shacham, Sharon ,  Penland, Robert C. ,  Noiman, Silvia ,  Gannon, Kimberley ,  Zhang, Zhaoda

IPC分类号： C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D491/048 ,  A61K31/4355

CPC分类号： C07D491/048 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04