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公开(公告)号：EP2307457B1
公开(公告)日：2018-06-13
申请号：EP09768692.7
申请日：2009-06-25
发明人： BORRAS, Leonardo , GUNDE, Tea , URECH, David
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13
CPC分类号： C07K16/241 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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公开(公告)号：EP3216803A1
公开(公告)日：2017-09-13
申请号：EP17151756.8
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David , GUNDE, Tea
IPC分类号： C07K16/22 , A61K39/395
摘要： The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及包含来自兔单克隆抗体的CDR的可溶且稳定的抗VEGF免疫结合剂。 所述抗体被设计用于诊断和/或治疗VEGF介导的病症。 还公开了用于表达本发明的重组抗体的杂交瘤，核酸，载体和宿主细胞，分离它们的方法以及所述抗体在医学中的用途。
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公开(公告)号：EP2307457A2
公开(公告)日：2011-04-13
申请号：EP09768692.7
申请日：2009-06-25
发明人： BORRAS, Leonardo , GUNDE, Tea , URECH, David
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13
CPC分类号： C07K16/241 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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公开(公告)号：EP2516461A1
公开(公告)日：2012-10-31
申请号：EP10798948.5
申请日：2010-12-21
发明人： BORRAS, Leonardo , GUNDE, Tea , URECH, David
IPC分类号： C07K16/00
CPC分类号： C07K16/42 , C07K16/241 , C07K2317/24 , C07K2317/34 , C07K2317/622 , C07K2317/76
摘要： A method for decreasing the immunogenicity of antibody variable domains is disclosed.
摘要翻译： 公开了降低抗体可变区的免疫原性的方法。
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公开(公告)号：EP2307454A2
公开(公告)日：2011-04-13
申请号：EP09768693.5
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David , GUNDE, Tea
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , C07K1/00 , C07K7/06 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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公开(公告)号：EP2307454B1
公开(公告)日：2017-01-18
申请号：EP09768693.5
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David , GUNDE, Tea
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , C07K1/00 , C07K7/06 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/92
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