发明公开
- 专利标题： STABLE AND SOLUBLE ANTIBODIES INHIBITING VEGF
- 专利标题（中）： 稳定且可溶的VEGF抑制抗体
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申请号： EP09768693.5申请日： 2009-06-25
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公开(公告)号： EP2307454A2公开(公告)日： 2011-04-13
- 发明人: BORRAS, Leonardo , URECH, David , GUNDE, Tea
- 申请人： ESBATech, an Alcon Biomedical Research Unit LLC
- 申请人地址： Wagistrasse 21 8952 Schlieren CH
- 专利权人： ESBATech, an Alcon Biomedical Research Unit LLC
- 当前专利权人： ESBATech, an Alcon Biomedical Research Unit LLC
- 当前专利权人地址： Wagistrasse 21 8952 Schlieren CH
- 代理机构： Molitor, Julia
- 优先权： US75697P 20080625; US75692P 20080625; US133212P 20080625; US155041P 20090224
- 国际公布： WO2009155724 20091230
- 主分类号： C07K16/22
- IPC分类号： C07K16/22 ; A61K39/395
摘要：
The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
公开/授权文献
- EP2307454B1 STABLE AND SOLUBLE ANTIBODIES INHIBITING VEGF 公开/授权日：2017-01-18
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