公开(公告)号：EP1270018B1

公开(公告)日：2005-04-13

申请号：EP02254563.6

申请日：2002-06-28

申请人： ETHICON, INC.

发明人： Timm, Debra A. ,  Hui, Henry K. ,  Roller, Mark B. ,  Melican, Mora C. ,  Hossainy, Syed

IPC分类号： A61L2/14 ,  A61L2/18 ,  A61L2/20 ,  A61L27/28 ,  A61L29/08 ,  A61L31/08 ,  A61L33/00 ,  A61M25/00 ,  B05D7/24

CPC分类号： A61L27/34 ,  A61L2/14 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0045

公开(公告)号：EP1270018A1

公开(公告)日：2003-01-02

申请号：EP02254563.6

申请日：2002-06-28

申请人： ETHICON, INC.

发明人： Timm, Debra A. ,  Hui, Henry K. ,  Roller, Mark B. ,  Melican, Mora C. ,  Hossainy, Syed

IPC分类号： A61L2/14 ,  A61L2/18 ,  A61L2/20 ,  A61L27/28 ,  A61L29/08 ,  A61L31/08 ,  A61L33/00 ,  A61M25/00 ,  B05D7/24

CPC分类号： A61L27/34 ,  A61L2/14 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0045

摘要： The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.

公开(公告)号：EP1559434A1

公开(公告)日：2005-08-03

申请号：EP05075683.2

申请日：2002-06-28

申请人： Ethicon, Inc.

发明人： Timm, Debra A. ,  Hui, Henry K. ,  Roller, Mark B. ,  Melican, Mora C. ,  Hossainy, Syed

IPC分类号： A61L2/14 ,  A61L2/18 ,  A61L2/20 ,  A61L27/28 ,  A61L29/08 ,  A61L31/08 ,  A61L33/00 ,  A61M25/00 ,  B05D7/24

CPC分类号： A61L27/34 ,  A61L2/14 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0045

摘要： The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.

摘要翻译： 本发明提供了用于医疗装置例如导管，组织工程支架或药物递送载体材料的材料和生物材料上的生物活性涂层的单步表面改性，接枝和灭菌的方法。 这可以包括可以从改进的抗血栓形成和生物相容性表面受益的任何医疗装置或植入物。 其它有关的装置实例可包括用于减少凝血和再狭窄的肝素或尿激酶涂层的支架，牙科或眼科植入物。 这些材料可以由多种聚合物组合物，如聚氨酯，聚酯，聚四氟乙烯，聚乙烯，聚甲基丙烯酸甲酯，聚乙烯醇，聚乙烯醇，聚硅氧烷，聚乳酸或乙醇酸，聚己内酯等组成。基材也可以是金属，陶瓷或生物学 衍生材料。